Prothrombin Complex Concentrate

DRUG13 trials

Sponsors

CSL Behring, University of Utah, Emory University, Fondation Ophtalmologique Adolphe de Rothschild, Octapharma

Conditions

Acquired Coagulation Factor DeficiencyBleedingBleeding in Cardiac SurgeryCardiac DefectCardiac Valve DiseaseCardiopulmonary BypassCoagulopathyCongenital Heart Disease

Phase 1

Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

TerminatedNCT00770718

University of UtahIntracranial Hemorrhage

Start: 2008-04-30End: 2010-04-30Updated: 2011-11-24

Phase 2

REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy

Bellal A. Joseph, MD, FACSCoagulopathy, Hemorrhage

Start: 2020-01-31End: 2023-01-31Target: 280Updated: 2019-06-10

Factor Replacement in Surgery

University Health Network, TorontoBleeding in Cardiac Surgery

Start: 2019-09-24End: 2020-12-31Updated: 2020-11-03

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery

TerminatedNCT04434001

IRCCS Policlinico S. DonatoBleeding, Cardiac Defect, Congenital Heart Disease +4

Start: 2020-02-27End: 2021-06-30Updated: 2021-11-03

Phase 3

Prothrombin Complex Concentrate for Anticoagulant Reversal

CompletedNCT00168077

CSL BehringAcquired Coagulation Factor Deficiency

Start: 2005-09-30End: 2006-11-30Target: 40Updated: 2011-02-11

Phase 4

CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients

CompletedNCT02777424

Fondation Ophtalmologique Adolphe de RothschildIntracranial Hemorrhages

Start: 2016-01-21End: 2019-03-27Updated: 2024-06-05

Coagulation in Cirrhosis

RecruitingNCT05667805

Medical University of ViennaLiver Cirrhosis

Start: 2023-01-19End: 2027-03-01Target: 400Updated: 2025-01-14

Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery

Not yet recruitingNCT06144112

Konkuk University Medical CenterLiver Diseases

Start: 2025-09-01End: 2026-03-31Target: 92Updated: 2025-07-20

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery

Konkuk University Medical CenterCardiac Valve Disease

Start: 2024-03-01End: 2025-04-01Target: 152Updated: 2023-11-22

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery

Konkuk University Medical CenterHip Osteoarthritis, Knee Disease, Prostate Cancer +1

Start: 2024-03-01End: 2025-04-01Target: 154Updated: 2024-01-02

Unknown Phase

Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass

CompletedNCT01352143

Emory UniversityCardiopulmonary Bypass

Start: 2011-03-31End: 2012-06-30Updated: 2013-11-20

Use of Prothrombin Complex Concentrate in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants

CompletedNCT03320603

OctapharmaEmergency Care for Severe Bleeding While on Anticoagulants

Start: 2017-10-13End: 2020-12-20Updated: 2021-07-27

Liberal or Adhere to Recommendations for PCC Management in Major Bleeding Following Trauma

RecruitingNCT06627218

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityTraumatic Bleeding

Start: 2021-01-01End: 2025-12-31Target: 650Updated: 2024-10-04

Related Papers

Comparison of 4-Factor Prothrombin Complex Concentrate With Frozen Plasma for Management of Hemorrhage During and After Cardiac Surgery

JAMA Network Open2021-04-0175 citations