Protamine sulfate

DRUG6 trials

Sponsors

Centre Hospitalier Universitaire De Bordeaux, Medical University of Warsaw, University of Michigan, London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's, St. Antonius Hospital

Conditions

Aortic Valve StenosisAtrial FibrillationCardiac Surgery With Cardiopulmonary BypassCatheter AblationIntracranial aneurysmsOpen Heart Surgery

Phase 2

"Evaluation of the impact of the dose of heparin on the occurrence of DWI ischemic lesions after embolization of unruptured intracranial aneurysm" "HARMONI"

Not yet recruitingCTIS2026-526530-13-00

Centre Hospitalier Universitaire De BordeauxIntracranial aneurysms

Target: 124Updated: 2026-09-07

Phase 4

Protamine Sulfate During Transcatheter Aortic Valve Implantation

CompletedNCT02974660

Medical University of WarsawAortic Valve Stenosis

Start: 2016-12-31End: 2020-09-30Updated: 2020-10-22

Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation

CompletedNCT03140631

University of MichiganAtrial Fibrillation, Catheter Ablation

Start: 2017-03-23End: 2018-04-03Updated: 2018-10-23

Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI)

CompletedNCT05774691

St. Antonius HospitalAortic Valve Stenosis

Start: 2023-11-01End: 2026-01-02Updated: 2026-05-20

Unknown Phase

Systematic Evaluation of Protamine Doze in Cardiac Surgery

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sCardiac Surgery With Cardiopulmonary Bypass

Start: 2018-09-20End: 2020-02-28Target: 100Updated: 2018-12-31

Dose for Reversal of Heparin After Cardiopulmonary Bypass

RecruitingNCT07477977

Sohag UniversityOpen Heart Surgery

Start: 2026-03-01End: 2026-09-01Target: 195Updated: 2026-05-05

Related Papers

Routine versus selective protamine administration to reduce bleeding after TAVI: Rationale and design of the POPular ACE TAVI trial.

2025-10-31

Minimum protamine dose required to neutralize heparin in cardiac surgery: a single-centre, prospective, observational cohort study.

2022-12-059 citations