Prograf 0
Sponsors
Centre Hospitalier Universitaire De Nantes, F. Hoffmann-La Roche AG, Vall D'hebron Institut De Recerca, Vall D'hebron Institut De Recerca, Charite Universitaetsmedizin Berlin KöR, Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Conditions
Antisynthetase syndrome-related interstitial lung diseaseCaucasian paediatric kidney transplant recipientsICD 10: Z94.4 Liver transplant statusKidney transplantPrimary Membranous Nephropathy (pMN)Renal transplantationSolid organ transplantation (Kidney)Solid organ transplantation (Liver)
Phase 1
A Phase I/IIa open label single ascending dose study to investigate the safety and tolerability of regulatory T cells as an adjunctive therapy in deceased-donor kidney recipients - ProTreg
RecruitingCTIS2024-514398-23-00
Start: 2024-06-10Target: 27Updated: 2025-09-10
A Phase I/IIa open label single ascending dose study to assess safety and tolerability of regulatory T cells to promote discontinuation of tacrolimus monotherapy in liver transplant recipients - LiveTreg
RecruitingCTIS2023-508261-32-00
Start: 2025-07-21Target: 27Updated: 2025-08-14
Phase 2
Phase 3
Prospective, multicenter, randomized, open-label, parallel-group controlled phase 3 study of tacrolimus minimization in kidney transplant recipients selected according to the AGORA algorithm for their low immunological risk and medium-term graft failure
RecruitingCTIS2022-502624-44-00
Start: 2024-12-10Target: 343Updated: 2024-10-21
A Phase III, Randomized, Open-Label Active Comparator-Controlled Multicenter Study to Evaluate Efficacy and Safety of Obinutuzumab in Patients with Primary Membranous Nephropathy
Active, not recruitingCTIS2023-506525-11-00
Start: 2021-04-19Target: 52Updated: 2025-02-03
Cyclophosphamide and Azathioprine vs Tacrolimus in antisynthetase syndrome-related interstitial lung disease : multicentric randomized phase III trial (CATR-PAT)
RecruitingCTIS2024-511868-83-00
Start: 2021-02-05Target: 76Updated: 2026-01-16
Phase 4
A multi-centre, open, prospective, randomized, parallel-group, 24-month study to compare the outcome of receiving continued immunosuppression versus stopping immunosuppression at 6 months to safely prevent human leukocyte antigen (HLA) sensitization in patients with late renal graft failure
RecruitingCTIS2023-506879-98-00
Start: 2024-01-22Target: 202Updated: 2024-09-25
Personalized tacrolimus treatment for pediatric kidney transplant recipients by using a dosing algorithm and a once-daily tacrolimus formulation
Not yet recruitingCTIS2024-511585-36-00
Target: 28Updated: 2024-06-28
Cognitive function after liver transplantation comparing Tacrolimus formulations
Active, not recruitingCTIS2024-513963-22-00
Start: 2020-12-09Target: 150Updated: 2025-05-19
TRANSPGx: A multicentre, controlled, randomised and single-blind, adaptive phase IV protocol to evaluate effectiveness and cost-effectiveness of pre-emptive genotyping strategy to optimise tacrolimus dosage in a pretransplant chronic kidney disease population cohort
RecruitingCTIS2024-516596-32-00
Start: 2025-03-31Target: 114Updated: 2025-08-08