Prochymal®

DRUG7 trials

Conditions

Crohn's DiseaseDiabetes Mellitus, Insulin-DependentGraft Versus Host DiseaseGraft-Versus-Host DiseaseJuvenile DiabetesMyocardial InfarctionType 1 DiabetesType 1 Diabetes Mellitus

Phase 2

PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)

CompletedNCT00690066

Mesoblast, Inc.Diabetes Mellitus, Insulin-Dependent, Juvenile Diabetes, Type 1 Diabetes +1

Start: 2008-06-11End: 2011-12-19Updated: 2026-03-11

Prochymal® (Human Adult Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction (AMI)

CompletedNCT00877903

Mesoblast, Inc.Myocardial Infarction

Start: 2009-03-30End: 2016-03-14Updated: 2026-03-11

Phase 3

Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD)

CompletedNCT00366145

Mesoblast, Inc.Graft Versus Host Disease

Start: 2006-08-17End: 2009-05-28Updated: 2022-02-10

Evaluation of PROCHYMAL® Adult Human Stem Cells for Treatment-resistant Moderate-to-severe Crohn's Disease

CompletedNCT00482092

Mesoblast, Inc.Crohn's Disease

Start: 2007-09-17End: 2014-09-15Updated: 2026-03-11

Efficacy and Safety of Prochymal® Infusion in Combination With Corticosteroids for the Treatment of Newly Diagnosed Acute Graft Versus Host Disease (GVHD)

CompletedNCT00562497

Mesoblast, Inc.Graft Versus Host Disease

Start: 2008-01-31End: 2010-05-20Updated: 2022-01-19

Evaluation of PROCHYMAL® for Treatment-refractory Moderate-to-severe Crohn's Disease

CompletedNCT01233960

Mesoblast, Inc.Crohn's Disease

Start: 2010-11-29End: 2014-09-15Updated: 2026-03-11

Unknown Phase

Prochymal® Expanded Access for Adults Who Have Failed Steroid Treatment for Acute Graft Versus Host Disease (GVHD)

NCT00826046

Mesoblast, Inc.Graft-Versus-Host Disease

Updated: 2020-03-09

Related Papers

Efficacy of Remestemcel-L Treatment in Steroid Refractory Acute Graft-Versus-Host Disease in Children: An Aggregate Analysis

Blood2020-11-051 citations

A Phase 3 Randomized Study of Remestemcel-L versus Placebo Added to Second-Line Therapy in Patients with Steroid-Refractory Acute Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation2019-09-07186 citations

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.

2016-08-11127 citations

The mesenchymal stromal cells dilemma--does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

2013-01-01344 citations