prazosin hydrochloride

DRUG9 trials

Sponsors

Vanderbilt University, Brian J Lipworth, US Department of Veterans Affairs, Seattle Institute for Biomedical and Clinical Research, Centre for Addiction and Mental Health

Conditions

Alcohol Use DisordersAllergic RhinitisCannabis DependenceCannabis Use DisorderCombat DisordersDementiaHeadacheHealthy

Phase 1

Treatment of Supine Hypertension in Autonomic Failure

CompletedNCT00223717

Vanderbilt UniversityHypertension

Start: 2001-01-31End: 2017-01-31Updated: 2017-10-13

The Effects of Prazosin on Dopamine in Healthy Humans: A PET Pilot Study

CompletedNCT01999530

Centre for Addiction and Mental HealthHealthy

Start: 2013-11-30End: 2016-08-31Updated: 2019-05-30

Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

CompletedNCT02266329

VA Office of Research and DevelopmentCombat Disorders, Headache, Mild Traumatic Brain Injury +3

Start: 2016-01-04End: 2023-09-30Updated: 2026-03-30

Phase 4

Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation

CompletedNCT00487032

Brian J LipworthAllergic Rhinitis, Rhinitis Medicamentosa, Tachyphylaxis

Start: 2008-05-31End: 2009-05-31Updated: 2019-04-12

Prazosin and Cerebrospinal Fluid (CSF) Biomarkers in Mild Traumatic Brain Injury (mTBI)

TerminatedNCT03221751

VA Office of Research and DevelopmentDementia

Start: 2016-12-01End: 2023-12-05Updated: 2024-02-26

Reducing Cannabis Overuse With Prazosin

CompletedNCT04721353

VA Puget Sound Health Care SystemCannabis Dependence, Cannabis Use Disorder, Posttraumatic Stress Disorder

Start: 2020-11-09End: 2025-06-01Updated: 2025-06-15

Unknown Phase

Effect of Prazosin on Neurophysiology and Cognition in Post-Traumatic Stress Disorder (PTSD)

WithdrawnNCT00890643

US Department of Veterans AffairsPosttraumatic Stress Disorder

Start: 2009-12-31End: 2011-09-30Updated: 2013-09-23

Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD)

CompletedNCT00990106

Seattle Institute for Biomedical and Clinical ResearchCombat Disorders, Sleep Disorders, Stress Disorders, Post-Traumatic

Start: 2009-09-30End: 2013-03-31Updated: 2018-05-23

Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD

CompletedNCT02226367

Seattle Institute for Biomedical and Clinical ResearchAlcohol Use Disorders, Combat Disorders, Stress Disorders, Posttraumatic

Start: 2015-01-31End: 2018-10-20Updated: 2023-02-03