Poziotinib
Sponsors
Samsung Medical Center, Spectrum Pharmaceuticals, Inc, Korean Association for the Study of Targeted Therapy, M.D. Anderson Cancer Center, Seoul National University Hospital
Conditions
Adenocarcinoma Lung Stage IVBreast CancerEGFR Exon 20 MutationERBB2 Gene MutationHER2 Gene MutationHNSCCHead and Neck NeoplasmsHealthy
Phase 1
A Study of Poziotinib in Combination With T-DM1 in HER2-Positive Breast Cancer
TerminatedNCT03429101
Start: 2018-07-13End: 2019-04-17Updated: 2021-01-15
A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult Participants
CompletedNCT04981704
Start: 2021-04-08End: 2021-08-17Updated: 2021-09-05
Phase 2
A Phase II, Single-Arm Trial of Poziotinib as Salvage Treatment in Patients With Metastatic Breast Cancer Who Has HER2 or EGFR Mutation or Activated AR or EGFR Pathway
CompletedNCT02544997
Start: 2015-09-30End: 2020-02-29Updated: 2020-07-07
Study of Poziotinib in Participants With HER2-Positive Metastatic Breast Cancer
CompletedNCT02659514
Start: 2016-02-22End: 2020-03-11Updated: 2022-03-11
Poziotinib in Stage IV Lung Adenocarcinoma With HER2 Mutation (KASTT001)
CompletedNCT02979821
Start: 2016-10-31End: 2017-12-31Updated: 2018-05-24
Poziotinib in EGFR Exon 20 Mutant Advanced NSCLC
TerminatedNCT03066206
Start: 2017-03-17End: 2026-02-16Updated: 2026-02-20
Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]
CompletedNCT03292250
Start: 2017-09-10End: 2022-03-10Updated: 2022-03-29
Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
TerminatedNCT03318939
Start: 2017-10-11End: 2023-04-03Updated: 2026-06-12
A Study to Allow Continued Dosing and/or Follow-up of Patients Who Have Had Previous Exposure to Poziotinib
TerminatedNCT03744715
Start: 2018-10-11End: 2023-03-03Updated: 2026-07-28
Poziotinib in Patients With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
TerminatedNCT04044170
Start: 2019-07-30End: 2020-04-13Updated: 2020-11-17