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Poziotinib

DRUG11 trials

Sponsors

Samsung Medical Center, Spectrum Pharmaceuticals, Inc, Korean Association for the Study of Targeted Therapy, M.D. Anderson Cancer Center, Seoul National University Hospital

Conditions

Adenocarcinoma Lung Stage IVBreast CancerEGFR Exon 20 MutationERBB2 Gene MutationHER2 Gene MutationHNSCCHead and Neck NeoplasmsHealthy

Phase 1

Phase 2

A Phase II, Single-Arm Trial of Poziotinib as Salvage Treatment in Patients With Metastatic Breast Cancer Who Has HER2 or EGFR Mutation or Activated AR or EGFR Pathway
CompletedNCT02544997
Samsung Medical CenterMetastatic Breast Cancer
Start: 2015-09-30End: 2020-02-29Updated: 2020-07-07
Study of Poziotinib in Participants With HER2-Positive Metastatic Breast Cancer
CompletedNCT02659514
Spectrum Pharmaceuticals, IncBreast Cancer
Start: 2016-02-22End: 2020-03-11Updated: 2022-03-11
Poziotinib in Stage IV Lung Adenocarcinoma With HER2 Mutation (KASTT001)
CompletedNCT02979821
Korean Association for the Study of Targeted TherapyAdenocarcinoma Lung Stage IV, HER2 Gene Mutation
Start: 2016-10-31End: 2017-12-31Updated: 2018-05-24
Poziotinib in EGFR Exon 20 Mutant Advanced NSCLC
TerminatedNCT03066206
M.D. Anderson Cancer CenterEGFR Exon 20 Mutation, ERBB2 Gene Mutation, Recurrent Lung Non-Small Cell Carcinoma +1
Start: 2017-03-17End: 2026-02-16Updated: 2026-02-20
Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]
CompletedNCT03292250
Seoul National University HospitalHead and Neck Neoplasms, HNSCC
Start: 2017-09-10End: 2022-03-10Updated: 2022-03-29
Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
TerminatedNCT03318939
Spectrum Pharmaceuticals, IncNSCLC
Start: 2017-10-11End: 2023-04-03Updated: 2026-06-12
A Study to Allow Continued Dosing and/or Follow-up of Patients Who Have Had Previous Exposure to Poziotinib
TerminatedNCT03744715
Spectrum Pharmaceuticals, IncBreast Cancer, NSCLC
Start: 2018-10-11End: 2023-03-03Updated: 2026-07-28
Poziotinib in Patients With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
TerminatedNCT04044170
Hanmi Pharmaceutical Company LimitedNSCLC
Start: 2019-07-30End: 2020-04-13Updated: 2020-11-17

Phase 3

Related Papers

Journal of Clinical Oncology2021-05-208 citations
Journal of Clinical Oncology2020-05-204 citations