powder and solvent for solution for injection
Sponsors
Antwerp University Hospital, Novartis Pharma AG, Biomarin Pharmaceutical Inc., Les Hopitaux Universitaires De Strasbourg, F. Hoffmann-La Roche AG
Conditions
HypochondroplasiaMultiple SclerosisProgressive Multiple SclerosisType 3 Von Willebrand Diseaserelapsing multiple sclerosis (RMS)
Phase 2
Metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration: a phase IIb triple-blind placebo-controlled randomized clinical trial (MACSiMiSE-BRAIN)
Active, not recruitingCTIS2023-503190-38-00
Start: 2023-11-23Target: 120Updated: 2025-11-07
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Vosoritide in Infants and Young Children with Hypochondroplasia, Aged 0 to < 36 Months
RecruitingCTIS2024-512261-14-00
Start: 2025-12-22Target: 30Updated: 2026-01-19
Phase 3
An Open-Label, Rater-Blind, Randomized, Multi-Center, Parallel-Arm, Active-Comparator Study to Assess the Efficacy and Tolerability of Ofatumumab 20mg SC monthly vs. First Line DMT - physician’s choice in the treatment of newly diagnosed RMS (STHENOS)
CompletedCTIS2023-507431-37-00
Start: 2021-07-23End: 2025-11-04Target: 186Updated: 2025-06-02
DISEASE MODIFYING THERAPIES WITHDRAWAL IN INACTIVE RELAPSING-REMITTING MULTIPLE SCLEROSIS PATIENTS AGED 55 AND OVER: A MULTICENTRIC, RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL - TWINS
RecruitingCTIS2024-513475-41-00
Start: 2025-02-03Target: 200Updated: 2024-11-08
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Vosoritide in Children with Hypochondroplasia
RecruitingCTIS2024-513129-22-00
Start: 2024-12-17Target: 22Updated: 2025-09-15
A Phase III, Multicenter, Open-Label Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Prophylaxis in Patients with Type 3 Von Willebrand Disease
RecruitingCTIS2024-515622-80-00
Start: 2025-06-04Target: 47Updated: 2025-06-27