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Posoleucel (ALVR105)

BIOLOGICAL3 trials

Sponsors

AlloVir

Conditions

Adenovirus InfectionBK Virus InfectionCytomegalovirus InfectionsEpstein-Barr Virus InfectionsHemorrhagic CystitisHuman Herpes Virus-6 InfectionJC Virus Infection

Phase 2

Posoleucel (ALVR105, Formerly Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant
CompletedNCT04693637
AlloVirAdenovirus Infection, BK Virus Infection, Cytomegalovirus Infections +3
Start: 2021-01-15End: 2023-01-19Updated: 2024-05-09
Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant
TerminatedNCT05305040
AlloVirAdenovirus Infection, BK Virus Infection, Cytomegalovirus Infections +3
Start: 2022-03-24End: 2024-01-30Updated: 2024-05-16

Phase 3

Study to Evaluate Viralym-M (ALVR105) for the Treatment of Virus-Associated Hemorrhagic Cystitis (HC)
TerminatedNCT04390113
AlloVirBK Virus Infection, Hemorrhagic Cystitis
Start: 2021-03-18End: 2024-01-30Updated: 2024-05-14

Related Papers

Final outcomes from a phase 2 trial of posoleucel in allogeneic hematopoietic cell transplant recipients
Blood Advances2024-04-0916 citations
Phenotypic and functional characterization of posoleucel, a multivirus-specific T cell therapy for the treatment and prevention of viral infections in immunocompromised patients.
2024-03-193 citations
Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study
Frontiers in Immunology2023-10-306 citations
Final Clinical Outcomes from a Phase 2 Trial of Posoleucel, an Off-the-Shelf, Multivirus-Specific T-Cell Therapy, for the Prevention of Clinically Significant Viral Infections Post-HCT
Blood2022-11-154 citations
Posoleucel (ALVR105), an Off-the-Shelf, Multivirus-Specific T-Cell Therapy, for the Prevention of Viral Infections Post-HCT: Results from an Open-Label Cohort of a Phase 2 Trial
Blood2021-11-058 citations