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Polygenic Risk Score

GENETIC7 trials

Sponsors

Mayo Clinic, Baker Heart and Diabetes Institute, Optithera, Catholic University of the Sacred Heart, Medical College of Wisconsin

Conditions

Breast CancerCardiovascular DiseasesCoronary Artery DiseaseCoronary Heart DiseaseDiabetes Mellitus, Type 2Diabetic Nephropathy Type 2Ovarian Cancer

Phase 1

Genetic Risk Estimation of Breast Cancer Prior to Preventive Medication Uptake
CompletedNCT02517593
Mayo ClinicBreast Cancer
Start: 2016-03-31End: 2019-12-01Updated: 2020-12-30

Unknown Phase

Genetic Risk Estimations for Influencing Decision Making in Women at High Risk of Breast Cancer, GENRE 2 Study
Active, not recruitingNCT04474834
Mayo ClinicBreast Cancer
Start: 2019-10-17End: 2029-12-15Updated: 2026-03-05
Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring
CompletedNCT04604353
Baker Heart and Diabetes InstituteCoronary Artery Disease
Start: 2020-12-07End: 2023-12-30Updated: 2024-08-22
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
RecruitingNCT06586203
OptitheraCardiovascular Diseases, Diabetes Mellitus, Type 2, Diabetic Nephropathy Type 2
Start: 2024-08-23End: 2028-08-23Target: 2714Updated: 2024-09-19
Feasibility of Innovative Approaches for Personalized Cardiovascular Prevention
RecruitingNCT06911294
Catholic University of the Sacred HeartCoronary Heart Disease
Start: 2025-02-10End: 2026-09-10Target: 120Updated: 2025-08-05
Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study
RecruitingNCT06935344
Catholic University of the Sacred HeartOvarian Cancer
Start: 2025-06-01End: 2027-05-01Target: 1300Updated: 2026-03-03
Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease
Not yet recruitingNCT07260552
Medical College of WisconsinCoronary Heart Disease
Start: 2027-06-01End: 2031-01-01Target: 200Updated: 2026-05-04

Related Papers

Feasibility of integrating genetic risk and digital health tools for cardiovascular prevention: the FitPreV protocol
Frontiers in Public Health2026-05-29
Abstract PD4-04: Impact of Polygenic Risk Scores on Breast Cancer Risk Assessment and Clinical Decision Making in Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2: Results from the Prospective Multisite GENRE-2 Clinical Trial
Clinical Cancer Research2026-02-17
Genetic Risk Scores and Wearables for CVD Prevention: Insights from the FItPreV Trial
European Journal of Public Health2025-10-01
Clinical impact of integrating polygenic risk scores with breast cancer risk assessment models: Results from the prospective multisite GENRE-2 clinical trial.
Journal of Clinical Oncology2025-05-282 citations
Screening for coronary artery disease among cancer survivors: rationale and design of the REDEEM-CAD study
Cardio-Oncology2025-02-04
Impact of a breast cancer (BC) polygenic risk score (PRS) on the decision to take preventive endocrine therapy (ET): The Genetic Risk Estimate (GENRE) trial.
Journal of Clinical Oncology2019-05-204 citations