Plenadren

DRUG3 trials

Sponsors

University of Roma La Sapienza, Ulla Feldt-Rasmussen, Neurocrine UK Limited

Conditions

Adrenal InsufficiencyPrimary Adrenal InsufficiencySecondary Adrenal Insufficiency

Phase 2

Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency

CompletedNCT05222152

Neurocrine UK LimitedPrimary Adrenal Insufficiency

Start: 2021-11-23End: 2023-10-18Updated: 2024-05-14

Phase 4

Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)

CompletedNCT02277587

University of Roma La SapienzaPrimary Adrenal Insufficiency, Secondary Adrenal Insufficiency

Start: 2014-03-31End: 2016-06-30Updated: 2019-04-25

Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism

Ulla Feldt-RasmussenAdrenal Insufficiency

Start: 2016-10-31End: 2017-12-31Target: 30Updated: 2017-02-23

Related Papers

Effects of modified release hydrocortisone on restoration of early morning cortisol, quality of life, and fatigue in adrenal insufficiency (The CHAMPAIN study): a randomised, double-blind, double-dummy, cross-over study comparing Chronocort and Plenadren.

2026-01-02

Circadian Rhythm of Glucocorticoid Administration Entrains Clock Genes in Immune Cells: A DREAM Trial Ancillary Study

The Journal of Clinical Endocrinology & Metabolism2018-05-2578 citations

Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial.

2017-12-08139 citations