plazomicin

DRUG4 trials

Sponsors

Achaogen, Inc.

Conditions

Acute PyelonephritisAcute Pyelonephritis (AP) Due to CREBloodstream Infections (BSI) Due to CREComplicated Urinary Tract InfectionComplicated Urinary Tract Infection (cUTI) Due to CREHealthy VolunteersHospital-Acquired Bacterial Pneumonia (HABP) Due to CREVentilator-Associated Bacterial Pneumonia (VABP) Due to CRE

Phase 1

A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin

CompletedNCT03270553

Achaogen, Inc.Healthy Volunteers

Start: 2017-08-31End: 2017-10-07Updated: 2017-10-11

Phase 2

A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP)

CompletedNCT01096849

Achaogen, Inc.Acute Pyelonephritis, Complicated Urinary Tract Infection

Start: 2010-07-13End: 2012-04-03Updated: 2018-08-22

Phase 3

A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)

CompletedNCT01970371

Achaogen, Inc.Acute Pyelonephritis (AP) Due to CRE, Bloodstream Infections (BSI) Due to CRE, Complicated Urinary Tract Infection (cUTI) Due to CRE +2

Start: 2014-09-16End: 2016-09-15Updated: 2018-10-16

A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP)

CompletedNCT02486627

Achaogen, Inc.Acute Pyelonephritis, Complicated Urinary Tract Infection

Start: 2016-01-11End: 2016-09-22Updated: 2018-08-23

Related Papers

Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study (ACHN-490-007).

2019-06-2815 citations

Once-Daily Plazomicin for Complicated Urinary Tract Infections.

2019-02-01139 citations

No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects

Clinical Pharmacology in Drug Development2019-01-037 citations

A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis

Antimicrobial Agents and Chemotherapy2018-01-2782 citations

Outcomes of high-dose levofloxacin therapy remain bound to the levofloxacin minimum inhibitory concentration in complicated urinary tract infections.

2016-11-256 citations