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Placebo vaginal ring

DRUG10 trials

Sponsors

International Partnership for Microbicides, Inc., Organon and Co, Oregon Health and Science University

Conditions

Contraception: Optional Applicator for Insertion of Vaginal RingDysmenorrheaHIV InfectionsHuman Immunodeficiency VirusMenopauseModerate to Severe Primary Dysmenorrhea

Phase 1

Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine)
CompletedNCT00700284
International Partnership for Microbicides, Inc.HIV Infections
Start: 2004-10-31End: 2005-01-31Updated: 2009-09-01
Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring
CompletedNCT01363037
International Partnership for Microbicides, Inc.HIV Infections
Start: 2011-11-30End: 2012-08-31Updated: 2015-09-10
Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng
CompletedNCT01755741
International Partnership for Microbicides, Inc.Human Immunodeficiency Virus
Start: 2013-02-28End: 2013-10-31Updated: 2018-03-29
Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring
CompletedNCT02920827
International Partnership for Microbicides, Inc.HIV Infections
Start: 2009-08-31End: 2010-04-30Updated: 2017-09-08

Phase 2

Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women
CompletedNCT02010593
International Partnership for Microbicides, Inc.Human Immunodeficiency Virus
Start: 2013-12-31End: 2015-04-30Updated: 2022-11-03

Phase 3

Performance and Safety of Vaginal Ring Applicator in Healthy Females (MK-8342A-063)
CompletedNCT02275546
Organon and CoContraception: Optional Applicator for Insertion of Vaginal Ring
Start: 2014-12-11End: 2015-04-10Updated: 2024-05-17
Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in Women With Primary Dysmenorrhea (With Optional Extension) (MK-8342B-059)
TerminatedNCT02668783
Organon and CoModerate to Severe Primary Dysmenorrhea
Start: 2016-02-11End: 2016-09-07Updated: 2024-05-28
Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060)
TerminatedNCT02668822
Organon and CoDysmenorrhea
Start: 2016-02-09End: 2016-09-12Updated: 2024-05-28

Phase 4

Estrogen and the Urogenital Microbiome in GSM
CompletedNCT03336437
Oregon Health and Science UniversityMenopause
Start: 2018-02-01End: 2019-08-23Updated: 2019-11-22

Unknown Phase

Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women
CompletedNCT01539226
International Partnership for Microbicides, Inc.HIV Infections
Start: 2012-03-27End: 2016-12-13Updated: 2022-10-19

Related Papers

Incremental value of non-pharmacokinetic adherence measures for dapivirine vaginal ring use in resource limited setting
Trials2026-06-11
Counterfactual Groups to Assess Vaccine or Treatment Efficacy in HIV Prevention Trials in High-Risk Populations in Uganda
Vaccines2025-08-08
Associations between intravaginal practices and incidence of sexually transmitted infections and bacterial vaginosis among women enrolled in the dapivirine vaginal ring trial (The Ring Study) in southwestern Uganda: a retrospective secondary analysis
BMJ Open2024-04-013 citations
Characterization of Viruses in Phase 3 and Phase 3b Trials (the Ring Study and the Dapivirine Ring Extended Access and Monitoring Trial) of the Dapivirine Vaginal Ring for Human Immunodeficiency Virus Type 1 Infection Risk Reduction
Clinical Infectious Diseases2022-11-044 citations
Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women
AIDS Patient Care and STDs2022-03-016 citations
Assessment of risk compensation following use of the dapivirine vaginal ring in southwestern Uganda
Sexually Transmitted Infections2021-02-046 citations
Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women
Clinical Infectious Diseases2018-08-0324 citations
Contraceptive Preference Among Women at Risk of HIV Acquisition in a Preparatory Screening Study for a Phase III Microbicide Trial in South Western Uganda.
2018-07-016 citations
Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women
New England Journal of Medicine2016-11-30454 citations
Safety and efficacy of the NuvaRing® Applicator in healthy females: a multicenter, open-label, randomized, 2-period crossover study.
2016-05-173 citations