Placebo to TQJ230 80 mg/0.8 mL Solution for injection in pre-filled syringe with needle safety device
Sponsors
Novartis Pharma AG
Conditions
ApheresisAtherosclerotic cardiovascular disease (ASCVD)Calcific Aortic Valve StenosisCardiovascular Disease
Phase 2
Phase 3
A randomized, double-blind, placebo-controlled, multicenter trial assessing the reduction of the rate of lipoprotein apheresis after treatment with pelacarsen (TQJ230) compared to placebo in patients with hyperlipoproteinemia(a) and established cardiovascular disease undergoing weekly lipoprotein apheresis in Germany
CompletedCTIS2023-508324-35-00
Start: 2022-08-19End: 2025-01-28Target: 51Updated: 2024-12-04
A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with pelacarsen (TQJ230) on major cardiovascular events in patients with established cardiovascular disease
Active, not recruitingCTIS2023-508292-37-00
Start: 2020-03-06Target: 4117Updated: 2026-01-27
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy, safety, and tolerability of pelacarsen (TQJ230) with background inclisiran in participants with atherosclerotic cardiovascular disease, and elevated LDL-C and Lp(a)
Not yet recruitingCTIS2024-516356-18-00
Target: 188Updated: 2025-08-11