Placebo to match RBV

DRUG5 trials

Sponsors

Gilead Sciences

Conditions

Chronic Hepatitis CHCV InfectionHepatitis CHepatitis C, Chronic

Phase 2

GS-5885, GS-9451, Tegobuvir and Ribovirin in Treatment-Experienced Subjects With Chronic Genotype 1a Or 1b Hepatitis C Virus (HCV) Infection

CompletedNCT01435226

Gilead SciencesHepatitis C, Chronic

Start: 2011-09-30End: 2013-07-31Updated: 2013-12-17

Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection

CompletedNCT01965535

Gilead SciencesHCV Infection

Start: 2013-10-31End: 2014-11-30Updated: 2018-11-16

Phase 3

Sofosbuvir + Ribavirin for 12 Weeks in Subjects With Chronic Genotype 2 or 3 Hepatitis C Infection Who Are Interferon Intolerant, Interferon Ineligible or Unwilling to Take Interferon

CompletedNCT01542788

Gilead SciencesChronic Hepatitis C

Start: 2012-03-31End: 2013-02-28Updated: 2014-05-19

Sofosbuvir + Ribavirin for 12 or 16 Weeks in Treatment Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection (FUSION)

CompletedNCT01604850

Gilead SciencesChronic Hepatitis C

Start: 2012-06-30End: 2013-05-31Updated: 2014-05-28

Sofosbuvir and Ribavirin in Treatment-Naive and Treatment-Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection

CompletedNCT01682720

Gilead SciencesHepatitis C

Start: 2012-09-30End: 2014-01-31Updated: 2014-10-09

Related Papers

Ledipasvir-sofosbuvir with or without ribavirin to treat patients with HCV genotype 1 infection and cirrhosis non-responsive to previous protease-inhibitor therapy: a randomised, double-blind, phase 2 trial (SIRIUS).

2015-03-13206 citations

Sofosbuvir and Ribavirin for Treatment of Chronic Hepatitis C in Patients Coinfected With Hepatitis C Virus and HIV: The Impact on Patient-Reported Outcomes

The Journal of Infectious Diseases2015-01-1256 citations

Patients' preferences and health utility assessment with SF‐6D and EQ‐5D in patients with chronic hepatitis C treated with sofosbuvir regimens

Alimentary Pharmacology & Therapeutics2014-07-1537 citations

Sofosbuvir and Ribavirin in HCV Genotypes 2 and 3

New England Journal of Medicine2014-05-04796 citations

Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options.

2013-04-23761 citations