Placebo of Enalapril

DRUG3 trials

Sponsors

Novartis Pharmaceuticals

Conditions

Chronic Heart Failure With Reduced Ejection FractionHeart Failure and Reduced Ejection FractionPediatric Heart Failure

Phase 2

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure

CompletedNCT02678312

Novartis PharmaceuticalsPediatric Heart Failure

Start: 2016-11-03End: 2022-01-03Updated: 2023-02-10

Phase 3

randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure

CompletedNCT02900378

Novartis PharmaceuticalsChronic Heart Failure With Reduced Ejection Fraction

Start: 2016-12-20End: 2018-04-11Updated: 2020-09-02

Phase 4

Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction

CompletedNCT02874794

Novartis PharmaceuticalsHeart Failure and Reduced Ejection Fraction

Start: 2016-08-17End: 2019-01-26Updated: 2021-01-05

Related Papers

Changes in cardiac structure and function are associated with health‐related quality of life in heart failure patients with reduced ejection fraction: Results from the <scp>EVALUATE</scp> ‐ <scp>HF</scp> trial

European Journal of Heart Failure2025-07-181 citations

Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial

Circulation2024-09-2531 citations

Baseline Characteristics of Pediatric Patients With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction in the PANORAMA-HF Trial

Circulation Heart Failure2023-01-0526 citations

Changes in cardiac biomarkers in association with alterations in cardiac structure and function, and health status in heart failure with reduced ejection fraction: <scp>the EVALUATE‐HF trial</scp>

European Journal of Heart Failure2022-05-1320 citations

Early B-Type Natriuretic Peptide Change in HFrEF Patients Treated With Sacubitril/Valsartan

JACC Heart Failure2022-01-1223 citations

Hemodynamic Effects of Sacubitril-Valsartan Versus Enalapril in Patients With Heart Failure in the EVALUATE-HF Study

Circulation Heart Failure2021-03-0112 citations

Effect of Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction

JAMA2019-09-02309 citations