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Placebo lozenge

DIETARY_SUPPLEMENT8 trials

Sponsors

Mayo Clinic, University of Minnesota, University of Iowa, Novozymes A/S, University of New Hampshire

Conditions

Dental PlaqueGingivitisMicrobial ColonizationOral CancerPeriodontal DiseaseSmokeless Tobacco UseSmokingTobacco Use Disorder

Phase 3

Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
CompletedNCT00392379
Mayo ClinicSmokeless Tobacco Use
Start: 2007-01-31End: 2009-03-31Updated: 2013-04-24

Phase 4

Pilot Study: Preoperative Nicotine Lozenges
CompletedNCT00586482
Mayo ClinicSmoking
Start: 2006-08-31End: 2013-01-31Updated: 2014-12-22

Unknown Phase

Medicinal Nicotine for Preventing Cue Induced Craving
CompletedNCT02347605
University of MinnesotaTobacco Use Disorder
Start: 2013-09-30End: 2015-01-31Updated: 2017-12-18
The Oral Microbiome in OSCC
CompletedNCT04925700
University of IowaOral Cancer
Start: 2022-04-20End: 2023-10-10Updated: 2023-11-18
Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals.
CompletedNCT05070507
Novozymes A/SDental Plaque, Gingivitis, Microbial Colonization
Start: 2021-01-08End: 2021-05-10Updated: 2021-10-07
Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals
TerminatedNCT05082103
Novozymes A/SDental Plaque
Start: 2021-09-15End: 2022-03-31Updated: 2022-06-09
Effect of Enzymes on Dental Biofilm Accumulation
CompletedNCT05579938
Novozymes A/SDental Plaque
Start: 2022-09-19End: 2022-11-20Updated: 2023-04-12
Probiotic Response in Periodontal Disease
Not yet recruitingNCT07718074
University of New HampshirePeriodontal Disease
Start: 2026-10-01End: 2028-07-01Target: 100Updated: 2026-07-21

Related Papers

The Effect of Enzymes on Dental Plaque: A Randomized Controlled Trial
Journal of Dental Research2025-07-17
Clinical Trial Data on the Mechanical Removal of 14-Day-Old Dental Plaque Using Accelerated Micro-Droplets of Air and Water (Airfloss)
Data2023-03-31