Placebo IVR

DRUG4 trials

Sponsors

CONRAD, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

Anti-Retroviral AgentContraceptionHIVHIV InfectionsPrevention

Phase 1

Phase I One-month Safety, PK, PD, and Acceptability Study of IVR Releasing TFV and LNG or TFV Alone

CompletedNCT02235662

CONRADContraception, HIV

Start: 2014-10-31End: 2015-12-31Updated: 2016-01-11

Safety and Pharmacokinetics of Intravaginal Rings Containing Vicriviroc (MK-4176) and/or MK-2048

CompletedNCT02356302

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2015-05-31End: 2016-03-31Updated: 2021-10-25

Pharmacokinetic and Safety Study of a 90 Day Intravaginal Ring Containing Tenofovir

CompletedNCT03670355

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2019-01-02End: 2019-09-25Updated: 2025-11-13

Phase 2

Tenofovir/Levonorgestrel Intravaginal Ring and Tenofovir Intravaginal Ring

CONRADAnti-Retroviral Agent, Contraception, HIV +1

Start: 2018-12-12End: 2020-04-30Target: 50Updated: 2020-01-14

Related Papers

Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya

Frontiers in Reproductive Health2023-06-136 citations

Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study

PLoS ONE2022-10-1016 citations

Acceptability of an intravaginal ring for simultaneously preventing HIV infection and pregnancy: Qualitative findings of the Kisumu Combined Ring Study, 2019.

2022-09-236 citations

Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using a 90-Day Tenofovir/Levonorgestrel Vaginal Ring

Frontiers in Cellular and Infection Microbiology2022-03-0819 citations

Users' Preferred Characteristics of Vaginal Rings for HIV Prevention: A Qualitative Analysis of Two Phase I Trials

AIDS Research and Human Retroviruses2021-12-311 citations

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings

PLoS ONE2019-05-2027 citations

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women.

2018-06-2852 citations