Placebo gas

DRUG4 trials

Sponsors

Washington University School of Medicine, University of Texas Southwestern Medical Center

Conditions

DepressionDepressive Disorder, MajorDepressive Disorder, Treatment-ResistantMajor Depressive DisorderMood DisordersPost-Concussion SyndromeSuicidal Ideation

Phase 1

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

TerminatedNCT02994433

Washington University School of MedicineDepressive Disorder, Major, Depressive Disorder, Treatment-Resistant

Start: 2017-01-27End: 2020-02-28Updated: 2021-08-02

Nitrous Oxide- Suicidal Ideation

Enrolling by invitationNCT03736538

Washington University School of MedicineDepression, Major Depressive Disorder, Mood Disorders +1

Start: 2018-10-30End: 2026-12-31Target: 50Updated: 2025-12-22

Phase 2

Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies

CompletedNCT03283670

Washington University School of MedicineDepressive Disorder, Major, Depressive Disorder, Treatment-Resistant

Start: 2016-11-22End: 2020-02-18Updated: 2022-04-04

Unknown Phase

Hyperbaric Oxygen Therapy for Post-Concussion Syndrome

CompletedNCT05643482

University of Texas Southwestern Medical CenterPost-Concussion Syndrome

Start: 2023-03-01End: 2025-05-12Updated: 2025-10-14

Related Papers

A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.

2021-06-0166 citations