Placebo for lenvatinib
Sponsors
Merck Sharp & Dohme LLC, Akeso
Conditions
Hepatocellular CarcinomaIncurable/Non-metastatic Hepatocellular CarcinomaMalignant MelanomaNon-small Cell Lung CancerUrothelial Carcinoma
Phase 3
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)
CompletedNCT03820986
Start: 2019-03-12End: 2024-11-01Updated: 2026-02-09
Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) (MK-7902-007/E7080-G000-314/LEAP-007)
CompletedNCT03829332
Start: 2019-03-13End: 2024-04-24Updated: 2026-02-19
Study of First-line Pembrolizumab (MK-3475) With Lenvatinib (MK-7902/E7080) in Urothelial Carcinoma Cisplatin-ineligible Participants Whose Tumors Express Programmed Cell Death-Ligand 1 and in Participants Ineligible for Platinum-containing Chemotherapy (MK-7902-011/E7080-G000-317/ LEAP-011)
CompletedNCT03898180
Start: 2019-05-06End: 2024-05-20Updated: 2026-02-05
Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study
CompletedNCT04676412
Start: 2019-10-23End: 2024-03-29Updated: 2025-04-04
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study
CompletedNCT04889118
Start: 2020-07-14End: 2024-11-01Updated: 2025-12-23
A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012)
CompletedCTIS2022-502116-36-00
Start: 2020-07-10End: 2025-11-26Target: 200Updated: 2025-08-26
A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma
RecruitingNCT06371157
Start: 2024-08-02End: 2026-05-23Target: 469Updated: 2025-03-12