Placebo for benralizumab for clinical trials is a sterile liquid solution presented in an accessorized prefilled syringe (apfs) for subcutaneous injection.
Sponsors
AstraZeneca AB
Conditions
Eosinophilic Granulomatosis with Polyangiitis (EGPA)Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of Frequent COPD
Exacerbations and Elevated Peripheral Blood EosinophilsSevere CRSwNP patients with asthma.
Phase 3
A Multicenter, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Benralizumab 100 mg in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of Frequent COPD Exacerbations and Elevated Peripheral Blood Eosinophils (RESOLUTE)
CompletedCTIS2022-503050-39-00
Start: 2019-11-12End: 2025-07-10Target: 236Updated: 2025-09-15
A Multicentre, Randomised, Double-Blind, Parallel-Group, Placebo-
Controlled Phase 3 Efficacy and Safety Study of Benralizumab in Patients
with Eosinophilic Chronic Rhinosinusitis with Nasal Polyps (ORCHID)
CompletedCTIS2023-507987-38-00
Start: 2021-10-14End: 2024-12-18Target: 79Updated: 2025-02-03
A Randomised, Double-blind, Active-controlled 52-week Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab Compared to Mepolizumab in the Treatment of Eosinophilic Granulomatosis with Polyangiitis (EGPA) in Patients Receiving Standard of Care Therapy (MANDARA Study).
Active, not recruitingCTIS2023-510248-19-00
Start: 2020-01-21Target: 72Updated: 2025-05-13