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Placebo - Microcrystalline Cellulose

DRUG2 trials

Sponsors

McMaster University

Conditions

Antibiotic-Associated DiarrheaAntibiotic-associated DiarrheaC-DifficileDiarrheaDuration of Mechanical VentilationICU and Hospital MortalityInfectionsLength of Hospital Stay

Phase 2

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial
CompletedNCT01782755
McMaster UniversityAntibiotic-Associated Diarrhea, C-Difficile, Duration of Mechanical Ventilation +5
Start: 2013-10-31End: 2015-01-31Updated: 2019-08-28

Phase 4

Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial
CompletedNCT02462590
McMaster UniversityAntibiotic-associated Diarrhea, C-Difficile, Diarrhea +2
Start: 2015-06-30End: 2020-11-17Target: 2650Updated: 2020-12-17

Related Papers

Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan.
2025-11-13
Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety.
2025-09-26
Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial.
2024-12-271 citations
Health economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): a cost-effectiveness analysis.
2022-10-267 citations
Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study
Journal of Critical Care2022-06-174 citations
Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients
JAMA2021-09-21202 citations
Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol
BMJ Open2020-06-015 citations
Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT
BMJ Open2019-06-0127 citations
Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study
Respiratory Research2018-12-0196 citations
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial
Trials2016-08-0153 citations
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: protocol for a feasibility randomized pilot trial
Pilot and Feasibility Studies2015-05-2318 citations