Placebo (PB)
Sponsors
UCB Pharma, Regeneron Pharmaceuticals
Conditions
Amyotrophic Lateral Sclerosis (ALS)Epilepsy, PartialHealthy VolunteersHealthy Volunteers With HyperlipidemiaMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Phase 1
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
RecruitingNCT05648214
Start: 2022-12-27End: 2027-08-10Target: 156Updated: 2025-12-22
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
RecruitingNCT06351592
Start: 2024-08-28End: 2031-06-05Target: 42Updated: 2026-02-27
A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults
Active, not recruitingNCT06452771
Start: 2024-06-27End: 2026-12-04Updated: 2026-02-20