Placebo (IV)

DRUG6 trials

Sponsors

Hoffmann-La Roche, Eli Lilly and Company, H. Lundbeck A/S, Janssen-Cilag Ltd., Astria Therapeutics, Inc.

Conditions

Crohn DiseaseDepressive Disorder, MajorHealthyHereditary AngioedemaUlcerative Colitis

Phase 1

A Study of LY3200327 in Healthy Participants

CompletedNCT02595736

Eli Lilly and CompanyHealthy

Start: 2015-11-30End: 2016-08-31Updated: 2016-09-12

A Safety Study of LY3462817 in Healthy Japanese and Non-Japanese Participants

CompletedNCT05440136

Eli Lilly and CompanyHealthy

Start: 2022-06-28End: 2023-03-08Updated: 2023-03-30

A Study of STAR-0215 in Healthy Adult Participants

CompletedNCT05477160

Astria Therapeutics, Inc.Hereditary Angioedema

Start: 2022-07-27End: 2023-11-17Updated: 2024-01-11

Phase 2

Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder

CompletedNCT02919501

H. Lundbeck A/SDepressive Disorder, Major

Start: 2016-09-27End: 2017-04-27Updated: 2018-06-20

Phase 3

A Study Comparing the Efficacy and Safety of Etrolizumab to Infliximab in Participants With Moderate to Severe Ulcerative Colitis Who Are Naïve to Tumor Necrosis Factor (TNF) Inhibitors

CompletedNCT02136069

Hoffmann-La RocheUlcerative Colitis

Start: 2014-12-24End: 2020-06-23Updated: 2021-12-03

A Study to Evaluate Efficacy and Safety of Ustekinumab Re-induction Therapy in Participants With Moderately to Severely Active Crohn's Disease

CompletedNCT03782376

Janssen-Cilag Ltd.Crohn Disease

Start: 2018-12-20End: 2023-01-10Updated: 2025-04-29

Related Papers

Ustekinumab Intravenous Reinduction after Secondary Loss of Response in Patients with Crohn's Disease.

2025-12-01

Safety and pharmacokinetics of long-acting plasma kallikrein inhibitor navenibart (STAR-0215) in healthy adults.

2025-03-282 citations

P098 The Endoscopic Severity Score Map (ESSM): An Artificial Intelligence scoring system providing accurate, objective and localised measurements of endoscopic disease severity in ulcerative colitis

Journal of Crohn s and Colitis2024-01-01

P206 Artificial Intelligence reproduces central reading for automated scoring of colonoscopies from multiple clinical trials in Ulcerative Colitis

Journal of Crohn s and Colitis2023-01-30

Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study.

2021-11-1778 citations

Etrolizumab for the Treatment of Ulcerative Colitis and Crohn's Disease: An Overview of the Phase 3 Clinical Program.

2020-05-2269 citations

Antibodies to watch in 2020.

2020-01-01328 citations

Intravenous vortioxetine to accelerate onset of effect in major depressive disorder

International Clinical Psychopharmacology2019-05-1616 citations