Pivmecillinam

DRUG9 trials

Sponsors

Uppsala Universitet, Odense University Hospital, Inmunotek S.L., Region Hovedstaden, Sykehuset i Vestfold HF

Conditions

Antibiotic ProphylaxisBacterial urinary tract infections and bloodstream infectionsBacteriuriaBladder Cancer Requiring CystectomyBloodstream InfectionComplicated urinary tract infections (cUTI) requiring hospitalisationCystectomyFebrile Urinary Tract Infection

Phase 2

Pivmecillinam as oral step-down treatment for Escherichia coli febrile urinary tract infection versus standard of care; a randomized controlled non-inferiority multicenter trial

RecruitingCTIS2023-503447-33-00

Uppsala Universitetfebrile Urinary Tract Infection (fUTI)

Start: 2025-11-13Target: 560Updated: 2025-10-08

Phase 3

Prediction and Prevention of Bloodstream Infections After Kidney Transplantation

Not yet recruitingNCT07407673

Susanne Dam Nielsen, MD, DMScAntibiotic Prophylaxis, Bacteriuria, Bloodstream Infection +6

Start: 2027-01-01End: 2041-07-01Target: 180Updated: 2026-10-16

Multicentre, randomised, double-blind, placebo-controlled clinical trial to confirm the efficacy, safety, and clinical impact of the mucosal bacterial therapeutic vaccine MV140 in women with non-complicated recurrent urinary tract infections (rUTIs).

Not yet recruitingCTIS2025-524377-16-00

Inmunotek S.L.Recurrent Non-Complicated Urinary Tract Infections (rUTIs).

Target: 252Updated: 2026-05-19

Prediction and Prevention of Bloodstream Infections After Kidney Transplantation - the PREDICT Study

Not yet recruitingCTIS2026-527337-63-00

Region HovedstadenBacterial urinary tract infections and bloodstream infections

Target: 180Updated: 2026-10-05

Phase 4

Treating Pyelonephritis an Urosepsis With Pivmecillinam

CompletedNCT03282006

Sykehuset i Vestfold HFPyelonephritis, Urinary Tract Infections

Start: 2017-09-29End: 2020-04-21Updated: 2020-04-22

Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.

CompletedNCT04959331

Fundacio d'Investigacio en Atencio Primaria Jordi Gol i GurinaUrinary Tract Infections

Start: 2021-11-02End: 2024-12-31Updated: 2025-09-08

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

RecruitingNCT06709196

Rigshospitalet, DenmarkAntibiotic Prophylaxis, Bladder Cancer Requiring Cystectomy, Cystectomy +2

Start: 2025-01-07End: 2027-01-31Target: 248Updated: 2025-01-09

Pivmecillinam as Oral Step-Down Treatment for Escherichia Coli Febrile Urinary Tract Infection Versus Standard of Care

RecruitingNCT07236944

Uppsala UniversityFebrile Urinary Tract Infection

Start: 2025-12-31End: 2029-03-31Target: 560Updated: 2025-12-17

Evidence based empirical antibiotic treatment for urinary tract infections requiring hospitalisation - TRI-AB trial

Not yet recruitingCTIS2024-520251-24-00

Odense University HospitalComplicated urinary tract infections (cUTI) requiring hospitalisation

Target: 618Updated: 2026-03-27

Related Papers

Multicentre, open-label, phase IV, randomised trial testing superiority of individualised targeted antibiotic prophylaxis over empiric prophylaxis at ureteral stent removal following cystectomy: study protocol for the REINFORCE trial.

2025-07-28

The efficacy of pivmecillinam in oral step-down treatment in hospitalised patients with E. coli bacteremic urinary tract infection; a single-arm, uncontrolled treatment study

BMC Infectious Diseases2022-05-1913 citations

Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical trial

BMJ Open2021-11-015 citations