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Pivmecillinam

DRUG8 trials

Sponsors

Uppsala Universitet, Odense University Hospital, Inmunotek S.L., Sykehuset i Vestfold HF, Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Conditions

Antibiotic ProphylaxisBladder Cancer Requiring CystectomyBloodstream InfectionComplicated urinary tract infections (cUTI) requiring hospitalisationCystectomyFebrile Urinary Tract InfectionIleal ConduitKidney Transplant Infection

Phase 2

Pivmecillinam as oral step-down treatment for Escherichia coli febrile urinary tract infection versus standard of care; a randomized controlled non-inferiority multicenter trial
RecruitingCTIS2023-503447-33-00
Uppsala Universitetfebrile Urinary Tract Infection (fUTI)
Start: 2025-11-13Target: 560Updated: 2025-10-08
Prediction and Prevention of Bloodstream Infections After Kidney Transplantation
Not yet recruitingNCT07407673
Susanne Dam Nielsen, MD, DMScBloodstream Infection, Kidney Transplant Infection
Start: 2027-01-01End: 2029-07-01Target: 150Updated: 2026-02-12

Phase 3

Multicentre, randomised, double-blind, placebo-controlled clinical trial to confirm the efficacy, safety, and clinical impact of the mucosal bacterial therapeutic vaccine MV140 in women with non-complicated recurrent urinary tract infections (rUTIs).
Not yet recruitingCTIS2025-524377-16-00
Inmunotek S.L.Recurrent Non-Complicated Urinary Tract Infections (rUTIs).
Target: 252Updated: 2026-05-19

Phase 4

Treating Pyelonephritis an Urosepsis With Pivmecillinam
CompletedNCT03282006
Sykehuset i Vestfold HFPyelonephritis, Urinary Tract Infections
Start: 2017-09-29End: 2020-04-21Updated: 2020-04-22
Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.
CompletedNCT04959331
Fundacio d'Investigacio en Atencio Primaria Jordi Gol i GurinaUrinary Tract Infections
Start: 2021-11-02End: 2024-12-31Updated: 2025-09-08
Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis
RecruitingNCT06709196
Rigshospitalet, DenmarkAntibiotic Prophylaxis, Bladder Cancer Requiring Cystectomy, Cystectomy +2
Start: 2025-01-07End: 2027-01-31Target: 248Updated: 2025-01-09
Pivmecillinam as Oral Step-Down Treatment for Escherichia Coli Febrile Urinary Tract Infection Versus Standard of Care
RecruitingNCT07236944
Uppsala UniversityFebrile Urinary Tract Infection
Start: 2025-12-31End: 2029-03-31Target: 560Updated: 2025-12-17
Evidence based empirical antibiotic treatment for urinary tract infections requiring hospitalisation - TRI-AB trial
Not yet recruitingCTIS2024-520251-24-00
Odense University HospitalComplicated urinary tract infections (cUTI) requiring hospitalisation
Target: 618Updated: 2026-03-27

Related Papers

Multicentre, open-label, phase IV, randomised trial testing superiority of individualised targeted antibiotic prophylaxis over empiric prophylaxis at ureteral stent removal following cystectomy: study protocol for the REINFORCE trial.
2025-07-28
The efficacy of pivmecillinam in oral step-down treatment in hospitalised patients with E. coli bacteremic urinary tract infection; a single-arm, uncontrolled treatment study
BMC Infectious Diseases2022-05-1913 citations
Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical trial
BMJ Open2021-11-015 citations