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PIVEKIMAB SUNIRINE

DRUG7 trials

Sponsors

AbbVie Deutschland GmbH & Co. KG, Fred Hutchinson Cancer Center, AbbVie

Conditions

Acute Myeloid LeukemiaAcute Myeloid Leukemia and other blood cancersCD123 positive Acute Myeloid LeukemiaMixed Phenotype Acute LeukemiaMyelodysplastic SyndromeMyelodysplastic/Myeloproliferative NeoplasmMyeloproliferative NeoplasmRelapsed or Refractory Acute Myeloid Leukemia; Acute Myeloid Leukemia

Phase 1

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms
Active, not recruitingNCT06034470
Fred Hutchinson Cancer CenterAcute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myelodysplastic/Myeloproliferative Neoplasm +2
Start: 2023-12-18End: 2029-05-31Updated: 2026-07-29
A Phase 1/2, Multicenter, Open-label Study of IMGN632 Monotherapy Administered Intravenously in Patients with CD123-positive Acute Myeloid Leukemia and Other CD123-positive Hematologic Malignancies
Active, not recruitingCTIS2024-514195-40-00
AbbVie Deutschland GmbH & Co. KGAcute Myeloid Leukemia and other blood cancers
Start: 2019-02-28Target: 34Updated: 2026-01-19
A Phase 1b/2 Study of IMGN632 as Monotherapy or Combination with Venetoclax and/or Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia
Active, not recruitingCTIS2024-514197-50-00
AbbVie Deutschland GmbH & Co. KGCD123 positive Acute Myeloid Leukemia
Start: 2020-01-17Target: 68Updated: 2025-12-19
A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
RecruitingNCT07306832
AbbVieAcute Myeloid Leukemia
Start: 2026-05-20End: 2030-03-01Target: 18Updated: 2026-09-09
A Phase 1b Study of the Safety and Pharmacokinetics of Pivekimab Sunirine in Pediatric Subjects with Relapsed or Refractory Acute Myeloid Leukemia (AML).
Not yet recruitingCTIS2024-520125-36-00
AbbVie Deutschland GmbH & Co. KGAcute Myeloid Leukemia, Relapsed or Refractory Acute Myeloid Leukemia; Acute Myeloid Leukemia
Target: 1Updated: 2026-04-20

Phase 2