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Phesgo 600 mg/600 mg solution for injection

DRUG13 trials

Sponsors

F. Hoffmann-La Roche AG, GBG Forschungs GmbH, Karolinska University Hospital, Seagen Inc., Medica Scientia Innovation Research S.L.

Conditions

Advanced CancerBreast CancerCancerEarly breast cancerEarly or Locally Advanced/ Inflammatory HER2-Positive Breast CancerHER2-POSITIVE EARLY BREAST CANCERHER2-positive early breast cancerHER2-positive unresectable locally recurrent or metastatic breast cancer (MBC).

Phase 2

A Randomized Trial of Trastuzumab Deruxtecan and Biology-Driven Selection of Neoadjuvant Treatment for HER2-positive Breast Cancer: ARIADNE
RecruitingCTIS2022-501504-95-00
Karolinska University HospitalNon-metastatic HER2-positive Breast Cancer
Start: 2023-06-23Target: 402Updated: 2025-08-18
A randomized, open-label, phase II trial comparing neoadjuvant endocrine therapy in combination with trastuzumab, pertuzumab +/- the PI3K inhibitor inavolisib in patients with HER2-positive, HR-positive, PIK3CA mutant early breast cancer - GeparPiPPa
RecruitingCTIS2022-501152-28-00
GBG Forschungs GmbHBreast Cancer
Start: 2022-12-21Target: 260Updated: 2025-12-01
A Multicenter, Open-Label, Single-Arm, Phase II Trial Exploring the Maintenance of Trastuzumab and Pertuzumab Following Trastuzumab Deruxtecan as Induction Treatment for HER2-positive Unresectable Locally Advanced or Metastatic Breast Cancer Patients (The DEMETHER Study)
RecruitingCTIS2023-507306-13-00
Medica Scientia Innovation Research S.L.HER2-positive unresectable locally recurrent or metastatic breast cancer (MBC).
Start: 2025-04-13Target: 132Updated: 2025-07-24
Improving public cancer care by implementing precision medicine in Norway A multi-cohort phase 2 treatment clinical study investigating efficacy of approved drugs outside indication in patients with advanced cancer. IMPRESS-Norway
RecruitingCTIS2023-507894-16-00
Oslo University Hospital HFCancer
Start: 2021-04-01Target: 6000Updated: 2026-01-22
Chemotherapy-Free pCR-Guided Strategy with subcutaneous trastuzumabpertuzumab and T-DM1 in HER2-positive early breast cancer (PHERGAIN-2)
Active, not recruitingCTIS2023-508738-32-00
Medica Scientia Innovation Research S.L.Previously untreated and histologically confirmed HER2-Positive (HER2[+]) early- stage breast cancer
Start: 2021-06-16Target: 396Updated: 2025-02-06
Genomics guided targeted post-neoadjuvant therapy in patients with early breast cancer – a multicenter, open-label, umbrella phase-II study (COGNITION-GUIDE)
RecruitingCTIS2024-514022-23-00
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen RechtsEarly breast cancer
Start: 2023-06-23Target: 240Updated: 2025-11-27
The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs to determine the Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile
Not yet recruitingCTIS2024-517478-68-01
HUS-YhtymaeAdvanced Cancer
Target: 250Updated: 2024-11-06

Phase 3

A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF GIREDESTRANT IN COMBINATION WITH PHESGO VERSUS PHESGO AFTER INDUCTION THERAPY WITH PHESGO+TAXANE IN PATIENTS WITH PREVIOUSLY UNTREATED HER2-POSITIVE, ESTROGEN RECEPTOR-POSITIVE LOCALLY-ADVANCED OR METASTATIC BREAST CANCER
Active, not recruitingCTIS2022-500014-26-00
F. Hoffmann-La Roche AGLocally-Advanced unresectable or Metastatic breast cancer (MBC)
Start: 2022-06-24Target: 218Updated: 2026-01-27
TIME AND MOTION STUDY OF A SUBCUTANEOUS FIXED DOSE COMBINATION OF PERTUZUMAB AND TRASTUZUMAB FOR THE TREATMENT OF PATIENTS WITH HER2-POSITIVE EARLY BREAST CANCER (PHATIMA)
CompletedCTIS2023-509321-50-00
Roche Farma S.A.HER2-POSITIVE EARLY BREAST CANCER
Start: 2021-04-15End: 2025-03-31Target: 34Updated: 2025-02-14
A randomized, double-blind, phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for metastatic HER2+ breast cancer (HER2CLIMB-05)
Active, not recruitingCTIS2023-503826-37-00
Seagen Inc.Unresectable locally-advanced or metastatic HER2+ breast cancer
Start: 2022-02-11Target: 249Updated: 2026-01-08
A Phase IIIB, Multinational, Multicenter, Randomized, Open-Label Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administrationin Participants with Early or Locally Advanced/ Inflammatory HER2-Positive Breast Cancer
CompletedCTIS2023-506380-33-00
F. Hoffmann-La Roche AGEarly or Locally Advanced/ Inflammatory HER2-Positive Breast Cancer
Start: 2022-06-28End: 2025-07-03Target: 32Updated: 2025-12-15
Atezolizumab, Pertuzumab and Trastuzumab with chemotherapy as neoadjuvant treatment of HER2 positive early high-risk and locally advanced breast cancer (APTneo)
Not yet recruitingCTIS2024-518026-32-00
Fondazione MichelangeloInvasive Breast Cancer
Target: 646Updated: 2025-08-12
Diagnostic HER2DX-guided trEatment For patIeNts wIth early-sTage HER2-positIVE breast cancer
RecruitingCTIS2025-521040-37-00
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I SunyerHER2-positive early breast cancer
Start: 2025-11-26Target: 224Updated: 2025-11-17

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