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Phase III

5 trials

Sponsors

Sanofi-aventis, Roche Nederland B.V., Astra Zeneca

Conditions

NIET-KLEINCELLIG LONGCARCINOOM (NSCLC)Non-small cell lung cancer / lung cancerbilaterale nasale polyposis nasal polyposisdemyelinating disease Multiple sclerosislokaal gevorderd of gemetastaseerde urotheliale blaaskanker bladder cancer locally advanced or metastatic urothelial bladder cancer

Phase 3

A Randomized, 24-Week Treatment, Double-blind, Placebo-controlled Efficacy and Safety Study of Dupilumab Every Other Week, in Patients with Bilateral Nasal Polyposis on a Background Therapy with Intranasal Corticosteroids
Active, not recruitingNL-OMON43359
Sanofi-aventisbilaterale nasale polyposis nasal polyposis
Start: 2017-06-15Target: 6Updated: 2024-02-28
A PHASE III, OPEN-LABEL, MULTICENTER, RANDOMIZED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF ATEZOLIZUMAB (ANTI*PD-L1 ANTIBODY) COMPARED WITH CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC UROTHELIAL BLADDER CANCER AFTER FAILURE WITH PLATINUM-CONTAINING CHEMOTHERAPY
Active, not recruitingNL-OMON45200
Roche Nederland B.V.lokaal gevorderd of gemetastaseerde urotheliale blaaskanker bladder cancer locally advanced or metastatic urothelial bladder cancer
Start: 2015-06-08Target: 52Updated: 2024-02-28
A Phase III, Open-label, Randomised, Multi-centre, International Study of MEDI4736, Given as Monotherapy or in Combination with Tremelimumab, Determined by PD-L1 Expression, Versus Standard of Care in Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (Stage IIIB IV) who Have Received at Least Two Prior Systemic Treatment Regimens Including One Platinum based Chemotherapy Regimen and Do Not Have Known EGFR TK Activating Mutations or ALK Rearrangements (ARCTIC)
Active, not recruitingNL-OMON45219
Astra ZenecaNon-small cell lung cancer / lung cancer
Start: 2015-11-26Target: 18Updated: 2024-02-28
AN OPEN-LABEL, MULTICENTER EXTENSION AND LONG-TERM OBSERVATIONAL STUDY IN PATIENTS PREVIOUSLY ENROLLED IN A GENENTECH- AND/OR F. HOFFMANN LA ROCHE LTD-SPONSORED ATEZOLIZUMAB STUDY
Active, not recruitingNL-OMON47480
Roche Nederland B.V.NIET-KLEINCELLIG LONGCARCINOOM (NSCLC)
Start: 2018-10-10Target: 11Updated: 2024-02-28
A Multi-center, Open-label, Single-arm, Before and After Switch Study to Evaluate the Efficacy, Safety and Tolerability of Alemtuzumab in Pediatric Patients with Relapsing Remitting Multiple Sclerosis (RRMS) with Disease Activity on Prior Disease Modifying Therapy (DMT)
NL-OMON49585
Sanofi-aventisdemyelinating disease Multiple sclerosis
Target: 1Updated: 2024-02-28