Phase I

BIOLOGICAL7 trials

Conditions

Advanced/metastatic Solid Tumor Malignant solid tumorBreast CancerCARCancerLung adenocarcinoma having the sensitive mutation to EGFR-TKILymphoblastic LeukemiaLymphoblastic Leukemia in ChildrenLymphoblastic Leukemia, Acute Adult

Phase 1

Phase I / II study for appropriate dose of Erlotinib in patients with lung adenocarcinoma having the sensitive mutation to epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI)

Active, not recruitingJPRN-UMIN000005556

Department of Respiratory Medicine National Center for Global health and MedicineLung adenocarcinoma having the sensitive mutation to EGFR-TKI

Start: 2010-12-01Target: 20Updated: 2025-07-18

Dual Anti-CD22/CD19 Chimeric Antigen Receptor-directed T Cells (CART2219.1) for Relapsed Refractory B-Lineage Leukaemia

NCT05429905

KK Women's and Children's HospitalCAR, Lymphoblastic Leukemia, Lymphoblastic Leukemia, Acute Adult +2

Start: 2022-07-18End: 2025-12-31Target: 48Updated: 2023-03-09

Phase 2

A phase I, first time in human, open-label, dose escalation study to investigate the safety, pharmacokinetics, and pharmacodynamics of anti-HER3 monoclonal antibody GSK2849330 in subjects with advanced HER3-positive solid tumors

Active, not recruitingNL-OMON44080

GlaxoSmithKlinegastric/gastroesophageal cancer head and neck cancer or NSCLC stage III-IV melanoma

Start: 2015-06-09Target: 40Updated: 2024-02-28

Unknown Phase

A phase I trial testing TH-302, a tumor-selective Hypoxia-Activated cytotoxic Prodrug, in combination with preoperative chemoradiotherapy in patients with distal esophageal and esophago-gastric junction adenocarcinoma

NL-OMON41947

Medisch Universitair Ziekenhuis Maastrichtesophageal cancer

Target: 18Updated: 2024-02-28

Phase I dose-escalation study of S 81694 administered intravenously in adult patients with advanced/metastatic solid tumours

Active, not recruitingNL-OMON47049

Institut de Recherches Internationales Servier I.R.I.SAdvanced/metastatic Solid Tumor Malignant solid tumor

Start: 2015-12-01Target: 24Updated: 2024-02-28

Trends in Modern Phase 1 Oncology Trials

CompletedNCT03676270

Institut BergoniéCancer

Start: 2014-01-31End: 2018-06-30Updated: 2021-01-07

Single Fraction Preoperative Radiotherapy for Early Stage Breast Cancer

RecruitingNCT04679454

European Institute of OncologyBreast Cancer

Start: 2021-07-31End: 2029-03-31Target: 79Updated: 2024-08-05

Related Papers

A narrative review for radiation oncologists to implement preoperative partial breast irradiation.

2023-08-316 citations

Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial—a study protocol

BMC Cancer2023-05-0918 citations

Single fraction ablative preoperative radiation treatment for early-stage breast cancer: the CRYSTAL study – a phase I/II clinical trial protocol

BMC Cancer2022-04-0217 citations