PfSPZ Challenge (7G8)

BIOLOGICAL2 trials

Sponsors

Sanaria Inc.

Conditions

MalariaMalaria,Falciparum

Phase 1

Sequential Optimization of Dose and Schedule of PfSPZ Vaccine

CompletedNCT02704533

Sanaria Inc.Malaria

Start: 2016-08-29End: 2018-12-31Updated: 2019-02-01

A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI

TerminatedNCT05604521

Sanaria Inc.Malaria, Malaria,Falciparum

Start: 2022-12-06End: 2023-09-05Updated: 2024-11-25

Related Papers

Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection.

2025-03-171 citations

The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections

PLoS Pathogens2023-06-2910 citations

A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection.

2022-08-2340 citations