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PfSPZ Challenge

BIOLOGICAL14 trials

Sponsors

Sanaria Inc., London School of Hygiene and Tropical Medicine, Medicines for Malaria Venture, National Institute of Allergy and Infectious Diseases (NIAID), Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

Conditions

HealthyMalariaMalaria,FalciparumPlasmodium FalciparumPlasmodium Falciparum Malaria

Phase 1

Experimental Human Malaria Infection by PfSPZ
CompletedNCT01086917
Sanaria Inc.Malaria
Start: 2010-08-31End: 2011-07-31Updated: 2015-04-21
Controlled Human Malaria Infection by Intradermal Injection of Plasmodium Falciparum Sporozoites in Tanzanian Adults
CompletedNCT01540903
Sanaria Inc.Malaria
Start: 2012-02-29End: 2013-08-31Updated: 2014-09-10
Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults
CompletedNCT01624961
Sanaria Inc.Malaria
Start: 2012-06-30End: 2013-02-28Updated: 2016-04-04
Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
CompletedNCT01728701
Sanaria Inc.Malaria, Plasmodium Falciparum
Start: 2012-09-30End: 2014-02-28Updated: 2017-05-15
Optimization of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults
CompletedNCT01771848
Sanaria Inc.Malaria
Start: 2012-12-31End: 2013-07-31Updated: 2016-04-04
Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis
CompletedNCT02115516
Sanaria Inc.Malaria, Plasmodium Falciparum Malaria
Start: 2014-04-30End: 2016-04-30Updated: 2017-05-15
Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults
CompletedNCT02132299
Sanaria Inc.Malaria, Plasmodium Falciparum Malaria
Start: 2014-04-30End: 2015-08-31Updated: 2016-04-27
Effect of Plasmodium Falciparum Exposure and Sickle Cell Trait on Infection Rates and Kinetics After IV Administration of PfSPZ Challenge
CompletedNCT02237586
Sanaria Inc.Malaria, Plasmodium Falciparum Malaria
Start: 2014-07-31End: 2015-02-28Updated: 2015-04-23
Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults
CompletedNCT03420053
Sanaria Inc.Malaria, Malaria,Falciparum
Start: 2018-02-07End: 2018-08-25Updated: 2019-04-05
Safety, Tolerability and Chemoprotective Activity of P218 in PfSPZ Challenge Model
CompletedNCT03707041
Medicines for Malaria VentureMalaria
Start: 2018-11-16End: 2019-06-03Updated: 2021-04-09
Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...
CompletedNCT03952650
National Institute of Allergy and Infectious Diseases (NIAID)Malaria
Start: 2019-05-23End: 2021-02-10Updated: 2022-07-12
Chemoprophylactic Activity of M5717 in PfSPZ Challenge Model
CompletedNCT04250363
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, GermanyHealthy
Start: 2020-02-17End: 2021-08-18Updated: 2024-05-01
Controlled Human Malaria Infection Transmission Model - Phase A
SuspendedNCT04280692
University of OxfordMalaria,Falciparum
Start: 2022-08-22End: 2026-08-31Updated: 2024-05-23

Unknown Phase

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