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PF-3512676

DRUG6 trials

Sponsors

Pfizer, Ronald Levy

Conditions

Breast NeoplasmsCarcinoma, Non-Small-Cell LungCarcinoma, Renal CellLymphomaLymphoma, Mantle-CellLymphoma, Non-HodgkinLymphoma, T-CellLymphoma, T-Cell, Cutaneous

Phase 1

CPG 7909 in Patients With Cutaneous T-Cell Lymphoma
CompletedNCT00043420
PfizerLymphoma, T-Cell, Cutaneous
Start: 2003-01-31End: 2007-03-31Updated: 2009-02-12

Phase 2

PF-3512676 (CPG 7909) Injection For Patients Who Completed An Oncology Study Using PF-3512676 (CPG 7909)
CompletedNCT00043368
PfizerBreast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell +2
Start: 2002-09-30End: 2007-06-30Updated: 2009-03-12
A Study Of Docetaxel Or Docetaxel Plus PF-3512676 To Treat Patients With Advanced Breast Cancer.
WithdrawnNCT00471159
PfizerBreast Neoplasms
Start: 2007-08-31Updated: 2015-05-04
Phase 1-2 of a CpG-Activated Whole Cell Vaccine Followed by Autologous Immunotransplant for MCL
CompletedNCT00490529
Ronald LevyLymphoma, Mantle-Cell
Start: 2009-08-31End: 2017-12-14Updated: 2020-01-13
A Phase 2 Intratumoral Injection PF-3512676 Plus Local Radiation in Low-Grade B-Cell Lymphomas
CompletedNCT00880581
Ronald LevyLymphoma, Lymphoma, Non-Hodgkin, Lymphomas: Non-Hodgkin +1
Start: 2009-01-31End: 2015-01-31Updated: 2017-03-14

Phase 3

Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in Patients With Advanced NSCLC
TerminatedNCT00254904
PfizerCarcinoma, Non-Small-Cell Lung
Start: 2005-11-30End: 2008-06-30Updated: 2015-03-30

Related Papers

Evaluation of Weight Gain and Overall Survival of Men Versus Women With Advanced Non-Small Cell Lung Cancer.
2025-12-011 citations
The relationship between weight gain during chemotherapy and outcomes in patients with advanced non‐small cell lung cancer
Journal of Cachexia Sarcopenia and Muscle2024-03-115 citations
Evaluation of weight gain and overall survival of patients with advanced non–small cell lung cancer (NSCLC) treated with first-line platinum-based chemotherapy.
Journal of Clinical Oncology2022-06-012 citations
Autologous tumor cell vaccine induces antitumor T cell immune responses in patients with mantle cell lymphoma: A phase I/II trial
The Journal of Experimental Medicine2020-06-1937 citations
PHASE I/II CLINICAL TRIAL OF AN ACTIVATED WHOLE TUMOR CELL VACCINE FOLLOWED BY TRANSFER OF IMMUNE T CELLS IN PATIENTS WITH MANTLE CELL LYMPHOMA
Hematological Oncology2017-06-012 citations
Activity of a Sting and a TLR9 Agonist As an “in Situ Therapeutic Vaccination” Against Lymphomas
Blood2016-12-021 citations
Phase I/II Clinical Trial of CpG-Activated Whole Cell Vaccine in Mantle Cell Lymphoma (MCL): Results in Safety and Efficacy from Planned Interim Analysis
Blood2015-12-033 citations
Natural Toll-like Receptor Agonists for in Situ Vaccination Lymphoma Immunotherapy
Blood2015-12-03
Dose-Escalated, Intratumoral TLR9 Agonist and Low-Dose Radiation Induce Abscopal Effects in Follicular Lymphoma
Blood2014-12-0612 citations
High-Throughput Sequencing Of T Cell Receptors Detects Signatures Of T Cell Repertoire That Predict MRD Status In Patients With Mantle Cell Lymphoma Undergoing Immunotransplantation
Blood2013-11-15