PF-07248144
Sponsors
Pfizer Inc., Unicancer, Pfizer
Conditions
Adult patients with advanced hormone receptor positive (HR+)Breast CancerHER2- breast cancer after at least a first line of endocrine therapy combined with CDK4/6 inhibitor in the metastatic settingHER2-Negative Advanced/Metastatic Breast CancerHealthy Adult ParticipantsHealthy AdultsHormone Receptor-PositiveLocally Advanced or Metastatic Castration-resistant Prostate Cancer
Phase 1
A Study to Learn About How Different Forms of Study Medicine PF-07248144 Are Taken Up Into the Blood in Healthy Adults
CompletedNCT07117799
Start: 2025-02-04End: 2025-07-11Updated: 2025-12-01
A Study to Learn if Multiple Doses of the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine PF-07248144
CompletedNCT07198035
Start: 2025-09-18End: 2026-01-15Updated: 2026-04-03
A Study to Learn if Itraconazole Changes How the Body Processes PF-07248144 (Study Medicine)
Active, not recruitingNCT07335419
Start: 2026-01-02End: 2026-03-21Updated: 2026-03-19
Phase 2
Study of PF-07248144 in Advanced or Metastatic Solid Tumors
RecruitingNCT04606446
Start: 2020-11-16End: 2029-08-10Target: 320Updated: 2026-04-16
UNLOCK - EPIBREAST, a phase II study of prifetrastat (PF-07248144), a KAT6 inhibitor, plus fulvestrant for advanced HR+/HER2- breast cancer with biomarkers analysis
Not yet recruitingCTIS2025-521982-29-00
Target: 51Updated: 2026-05-22
Phase 3
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
RecruitingNCT07062965
Start: 2025-08-05End: 2030-11-04Target: 400Updated: 2026-05-06
C4551002 - An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator’s Choice of Therapy in Adult Participants with Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy
RecruitingCTIS2025-520566-22-00
Start: 2025-11-10Target: 153Updated: 2026-01-27