PF-04136309

DRUG5 trials

Sponsors

Pfizer, Washington University School of Medicine

Conditions

HealthyHepatitis C, ChronicMetastatic Pancreatic Ductal AdenocarcinomaOsteoarthritis, KneePancreatic Neoplasms

Phase 1

FOLFIRINOX Plus PF-04136309 in Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

CompletedNCT01413022

Washington University School of MedicinePancreatic Neoplasms

Start: 2012-04-30End: 2016-09-30Target: 44Updated: 2016-09-19

Food Effect Study PF-04136309

CompletedNCT02598206

Start: 2015-12-31End: 2016-05-31Updated: 2018-04-11

Phase 2

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee

CompletedNCT00689273

PfizerOsteoarthritis, Knee

Start: 2008-08-05End: 2008-11-27Updated: 2021-07-13

Safety And Efficacy Of Oral PF-4136309 In Patients With Chronic Hepatitis C Infection And Abnormal Liver Enzymes

TerminatedNCT01226797

PfizerHepatitis C, Chronic

Start: 2011-01-17End: 2012-02-09Updated: 2023-07-27

Ph1b/2 Study of PF-04136309 in Combination With Gem/Nab-P in First-line Metastatic Pancreatic Patients

TerminatedNCT02732938

PfizerMetastatic Pancreatic Ductal Adenocarcinoma

Start: 2016-05-04End: 2017-10-10Updated: 2019-02-04

Related Papers

Abstract 6213: <i>De</i>termination of permissive and restraining <i>c</i>ancer-<i>a</i>ssociated <i>f</i>ibroblast (DeCAF) subtypes

Cancer Research2024-03-22

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.

2019-07-12144 citations

Abstract B42: Targeting cancer cell CCR2 enhances synergistic immune surveillance in breast cancer

Cancer Research2018-05-14

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.

2016-04-04628 citations