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Pemetrexed Fresenius Kabi 25 mg/ml concentrate for solution for infusion

DRUG10 trials

Sponsors

Regeneron Pharmaceuticals Inc., Gilead Sciences Inc., F. Hoffmann-La Roche AG, Bio-Thera Solutions Ltd., Bayer AG

Conditions

Advanced Non-Small Cell Lung CancerAdvanced non-small cell lung cancer with HER2 (ERBB2) mutationAdvanced/metastatic non-small cell lung cancer (NSCLC)Previously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung CancerPreviously Untreated Metastatic Non-Squamous Non-Small Cell Lung CancerResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)Solid TumoursStage IB-IIIA NSCLC Patients with uncommon EGFR Mutations

Phase 1

Phase 2

Phase 3

A Phase I/III, Multi-center, Randomized, Double-blind Study of BAT3306 plus Chemotherapy versus Keytruda® plus Chemotherapy to Evaluate Pharmacokinetics, Efficacy, and Safety in Participants with Stage IV Non-squamous Non-small Cell Lung Cancer.
CompletedCTIS2024-510640-32-00
Bio-Thera Solutions Ltd.Stage IV Non-squamous non-small cell lung cancer
Start: 2024-10-16End: 2025-05-08Target: 23Updated: 2025-03-13
(22615 SOHO-02) A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with HER2-activating mutations
RecruitingCTIS2024-511319-91-00
Bayer AGAdvanced non-small cell lung cancer with HER2 (ERBB2) mutation
Start: 2024-10-23Target: 145Updated: 2025-08-26
A Double-Blind, Randomized, Active-Controlled, Parallel-Group, Phase 3 Study to Compare Efficacy and Safety of CT-P51 and Keytruda in Combination with Platinum-Pemetrexed Chemotherapy in Patients with Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer
RecruitingCTIS2024-514048-98-00
Celltrion Inc.Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer
Start: 2025-01-30Target: 210Updated: 2025-04-22
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
F. Hoffmann-La Roche AGResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)
Start: 2025-05-05Target: 54Updated: 2025-11-10
TACTI-004, a double-blinded, randomized phase 3 trial in patients with advanced/metastatic non-small cell lung cancer (NSCLC) receiving eftilagimod alfa (MHC class II agonist) in combination with pembrolizumab (PD-1 antagonist) and chemotherapy.
RecruitingCTIS2024-513621-23-00
ImmutepAdvanced/metastatic non-small cell lung cancer (NSCLC)
Start: 2025-04-18Target: 363Updated: 2026-01-12
A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Plus Adjuvant Chemotherapy Versus Placebo Plus Adjuvant Chemotherapy in Stage IB-IIIA NSCLC Patients with Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)
RecruitingCTIS2025-521775-31-00
Taiho Oncology Inc.Stage IB-IIIA NSCLC Patients with uncommon EGFR Mutations
Start: 2025-11-12Target: 126Updated: 2026-01-12
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
F. Hoffmann-La Roche AGPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung Cancer
Start: 2025-10-28Target: 282Updated: 2026-01-13