Pemetrexed Accord 25 mg/ml concentrate for solution for infusion
Sponsors
Incyte Corp., AstraZeneca AB, Institut Gustave Roussy, F. Hoffmann-La Roche AG, Oncomatryx Biopharma S.L.
Conditions
Advanced/Metastatic Non-squamous Non-Small Cell Lung CancerMetastatic Non-Small Cell Lung Cancer (mNSCLC)Metastatic nonsquamous or squamous non-small cell lung cancerNSQ NSCLCNon-Small Cell Lung CancerPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung CancerResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)SQ
Phase 1
A Phase Ib/II, Open-Label, Multicenter Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination with Other Anti-Cancer Therapies in Patients with Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer with a KRAS G12C Mutation
RecruitingCTIS2023-507171-22-00
Start: 2023-06-21Target: 116Updated: 2025-10-27
Phase 1b/2 Trial of OMTX705, an Anti-Fibroblast Activation Protein Antibody-Drug Conjugate, in Combination with Carboplatin, Pemetrexed and Tislelizumab in Patients with Advanced/Metastatic Non-squamous Non-Small Cell Lung Cancer
Not yet recruitingCTIS2025-521989-95-00
Target: 88Updated: 2025-12-12
Phase 2
Phase 3
A Phase III, Two- Arm, Parallel, Randomized, Multi-Center, Open‑Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) in Combination with Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) (eVOLVE-Lung02)
SuspendedCTIS2023-503298-39-00
Start: 2024-06-13Target: 437Updated: 2025-12-15
A Randomized, Double Blind, Phase 3 Study of Platinum-Based Chemotherapy With or Without INCMGA00012 in First-Line Metastatic Squamous and Nonsquamous Non–Small Cell Lung Cancer (POD1UM-304)
Active, not recruitingCTIS2022-501987-16-00
Start: 2020-10-02Target: 14Updated: 2025-08-05
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
Start: 2023-03-28Target: 87Updated: 2025-11-17
First-line immunotherapy-based standard of care and local ablative treatments for oligometastatic non-small cell lung cancer patients: a randomized, multicentre, open-label phase III study (OliGRAIL)
RecruitingCTIS2023-503326-39-00
Start: 2025-03-06Target: 130Updated: 2025-08-26
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
Start: 2025-05-05Target: 54Updated: 2025-11-10
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
Start: 2025-10-28Target: 282Updated: 2026-01-13