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Pemetrexed Accord 25 mg/ml concentrate for solution for infusion

DRUG9 trials

Sponsors

Incyte Corp., AstraZeneca AB, Institut Gustave Roussy, F. Hoffmann-La Roche AG, Oncomatryx Biopharma S.L.

Conditions

Advanced/Metastatic Non-squamous Non-Small Cell Lung CancerMetastatic Non-Small Cell Lung Cancer (mNSCLC)Metastatic nonsquamous or squamous non-small cell lung cancerNSQ NSCLCNon-Small Cell Lung CancerPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung CancerResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)SQ

Phase 1

Phase 2

Phase 3

A Phase III, Two- Arm, Parallel, Randomized, Multi-Center, Open‑Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) in Combination with Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) (eVOLVE-Lung02)
SuspendedCTIS2023-503298-39-00
AstraZeneca ABMetastatic Non-Small Cell Lung Cancer (mNSCLC)
Start: 2024-06-13Target: 437Updated: 2025-12-15
A Randomized, Double Blind, Phase 3 Study of Platinum-Based Chemotherapy With or Without INCMGA00012 in First-Line Metastatic Squamous and Nonsquamous Non–Small Cell Lung Cancer (POD1UM-304)
Active, not recruitingCTIS2022-501987-16-00
Incyte Corp.Metastatic nonsquamous or squamous non-small cell lung cancer
Start: 2020-10-02Target: 14Updated: 2025-08-05
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
AstraZeneca ABNon-Small Cell Lung Cancer
Start: 2023-03-28Target: 87Updated: 2025-11-17
First-line immunotherapy-based standard of care and local ablative treatments for oligometastatic non-small cell lung cancer patients: a randomized, multicentre, open-label phase III study (OliGRAIL)
RecruitingCTIS2023-503326-39-00
Institut Gustave RoussySynchronous oligometastatic non-small cell lung cancer (NSCLC)
Start: 2025-03-06Target: 130Updated: 2025-08-26
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
F. Hoffmann-La Roche AGResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)
Start: 2025-05-05Target: 54Updated: 2025-11-10
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
F. Hoffmann-La Roche AGPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung Cancer
Start: 2025-10-28Target: 282Updated: 2026-01-13