PCV10

BIOLOGICAL3 trials

Sponsors

Murdoch Childrens Research Institute, London School of Hygiene and Tropical Medicine, University of Witwatersrand, South Africa

Conditions

Invasive Pneumococcal Disease, Protection AgainstMeningitisPneumococcal InfectionPneumococcal VaccinesPneumoniaStreptococcus Pneumoniae Infection

Phase 2

Trial of Pneumococcal Vaccine Schedules in Ho Chi Minh City, Vietnam

CompletedNCT01953510

Murdoch Childrens Research InstitutePneumococcal Vaccines

Start: 2013-09-30End: 2021-11-08Updated: 2022-09-14

Phase 4

The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants

CompletedNCT03489018

London School of Hygiene and Tropical MedicineInvasive Pneumococcal Disease, Protection Against, Pneumococcal Infection, Streptococcus Pneumoniae Infection

Start: 2019-03-21End: 2024-11-01Updated: 2024-11-12

Unknown Phase

Persistence of Immunogenicity Following Reduced PCV Dosing Schedules in South African Children

CompletedNCT04275284

University of Witwatersrand, South AfricaMeningitis, Pneumonia

Start: 2020-02-14End: 2022-12-01Updated: 2024-08-23

Related Papers

Immunogenicity up to age 5 years following a single-dose or two-dose infant primary series of 10-valent or 13-valent pneumococcal conjugate vaccine each followed by a booster dose in South Africa: extended follow-up of a single-centre, open-label, non-inferiority, randomised controlled trial.

2026-09-08

Serotype-specific immunity and association with pneumococcal carriage following 3+1, 3+0 and 2+1 schedules of 10-valent pneumococcal conjugate vaccine.

2026-03-12

Determining the dose-response relationship for pneumococcal conjugate vaccines: a nested analysis of the fractional dose PCV trial.

2026-01-06

Relationship between IL-17_A and pneumococcal carriage in children aged under two years: data from a randomised controlled trial in Vietnam.

2025-12-23

Single priming and a booster dose of 10-valent and 13-valent pneumococcal conjugate vaccine (PCV) maintains suppression of vaccine serotype colonization in South African children at 3, 4, and 5 years of age: a single-centre, open-labelled, randomized trial

Expert Review of Vaccines2024-10-172 citations

Fractional Doses of Pneumococcal Conjugate Vaccine — A Noninferiority Trial

New England Journal of Medicine2024-09-268 citations

Effect of different schedules of ten-valent pneumococcal conjugate vaccine on pneumococcal carriage in Vietnamese infants: results from a randomised controlled trial.

2022-12-0313 citations

Immunogenicity of alternative ten-valent pneumococcal conjugate vaccine schedules in infants in Ho Chi Minh City, Vietnam: results from a single-blind, parallel-group, open-label, randomised, controlled trial.

2021-06-2319 citations

Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam.

2021-03-1917 citations

Immunogenicity and reactogenicity of ten-valent versus 13-valent pneumococcal conjugate vaccines among infants in Ho Chi Minh City, Vietnam: a randomised controlled trial.

2019-04-0838 citations

Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled trial

BMJ Open2018-06-0126 citations

Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea.

2017-12-257 citations