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PCNA Inhibitor AOH1996

DRUG2 trials

Sponsors

City of Hope Medical Center

Conditions

LeiomyosarcomasNon-Small Cell Lung CancerOsteosarcomaOvarian CancerPancreatic CancerRecurrent Acute Myeloid LeukemiaRefractory Acute Myeloid LeukemiaRefractory Malignant Solid Neoplasm

Phase 1

AOH1996 for the Treatment of Refractory Solid Tumors
RecruitingNCT05227326
City of Hope Medical CenterLeiomyosarcomas, Non-Small Cell Lung Cancer, Osteosarcoma +4
Start: 2022-08-12End: 2029-09-13Target: 92Updated: 2026-07-28
A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
RecruitingNCT06763341
City of Hope Medical CenterRecurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
Start: 2025-07-30End: 2027-01-16Target: 12Updated: 2026-07-27

Related Papers

Abstract 5140: Development of hydrophilic and metabolically stable heterocyclic AOH1996 analogues for pediatric AML oral liquid formulations
Cancer Research2026-04-03
Abstract 3864: AOH1996: A multi-faceted inhibitor of metastasis via PCNA and tumor microenvironment targeting
Cancer Research2025-04-211 citations