Participants are randomised using an online randomisation system in a 1:1 ratio between the 2 treatment arms. Minimisation will be used for age, gender, duration of symptoms before randomisation and c

2 trials

Sponsors

University Hospital Southampton NHS Foundation Trust

Conditions

Appendicitis Digestive System Unspecified appendicitisSpecialty: Children, Primary sub-specialty: Gastroenterology, Hepatology and Nutrition

Unknown Phase

Non operative treatment of children with appendicitis vs appendectomy – A feasibility study

Active, not recruitingISRCTN15830435

University Hospital Southampton NHS Foundation TrustSpecialty: Children, Primary sub-specialty: Gastroenterology, Hepatology and Nutrition

Start: 2017-02-13Target: 65Updated: 2023-06-20

Non-operative treatment of children with appendicitis vs appendectomy

Active, not recruitingISRCTN16720026

University Hospital Southampton NHS Foundation TrustAppendicitis Digestive System Unspecified appendicitis

Start: 2022-01-31Target: 376Updated: 2026-08-03

Related Papers

The clinical and cost effectiveness of a conservative treatment pathway compared to appendicectomy in children with uncomplicated acute appendicitis: study protocol for a randomised controlled multi-centre open-label parallel-group non-inferiority trial (CONTRACT 2 trial) in the United Kingdom (UK).

2025-12-04

Assessing micro- vs macro-costing approaches for treating appendicitis in children with appendicectomy or non-operatively

Quality of Life Research2023-06-073 citations

Patient-centred outcomes following non-operative treatment or appendicectomy for uncomplicated acute appendicitis in children

BMJ Paediatrics Open2023-02-0130 citations

Conservative treatment for uncomplicated appendicitis in children: the CONTRACT feasibility study, including feasibility RCT

Health Technology Assessment2021-02-0158 citations

CONservative TReatment of Appendicitis in Children: a randomised controlled feasibility Trial (CONTRACT)

Archives of Disease in Childhood2021-01-1328 citations

Enhancing communication, informed consent and recruitment in a paediatric urgent care surgical trial: a qualitative study

BMC Pediatrics2020-03-3014 citations

CONTRACT Study - CONservative TReatment of Appendicitis in Children (feasibility): study protocol for a randomised controlled Trial.

2018-03-0222 citations