Partial Breast Irradiation

RADIATION12 trials

Sponsors

Danish Breast Cancer Cooperative Group, Institut du Cancer de Montpellier - Val d'Aurelle, University of Chicago, Regione Emilia-Romagna, Fudan University

Conditions

Breast CancerBreast CarcinomaCancer of the BreastDuctal Breast Carcinoma In SituEarly-Stage Breast CarcinomaEarly-Stage Invasive Breast CarcinomaEstrogen Receptor NegativeHER2 Positive Breast Carcinoma

Phase 2

Hypofractionated Partial Breast Irradiation in Treating Patients With Early Stage Breast Cancer

SuspendedNCT03077841

M.D. Anderson Cancer CenterDuctal Breast Carcinoma In Situ, Early-Stage Breast Carcinoma, Invasive Breast Carcinoma +7

Start: 2017-03-06End: 2027-11-08Target: 928Updated: 2026-09-14

Single FrAction Interstitial BreaSt BracHytherApy

Not yet recruitingNCT07654257

Virginia Commonwealth UniversityBreast Cancer

Start: 2026-09-01End: 2036-09-30Target: 134Updated: 2026-06-18

Phase 3

Partial Breast Irradiation Without Sentinel Lymph Node Biopsy in Low-Risk Early Breast Cancer

Not yet recruitingNCT07757958

Samsung Medical CenterBreast Cancer, Early-Stage Invasive Breast Carcinoma, Node-negative Breast Cancer

Start: 2026-08-01End: 2036-06-01Target: 520Updated: 2026-08-11

Unknown Phase

Partial Breast Versus Whole Breast Irradiation in Elderly Women Operated on for Early Breast Cancer

Active, not recruitingNCT00892814

Danish Breast Cancer Cooperative GroupBreast Carcinoma

Start: 2009-05-14End: 2026-03-31Updated: 2020-02-25

Breast-Conserving Surgery and Whole-Breast Radiation Therapy With or Without Additional Radiation Therapy to the Tumor in Treating Women With Ductal Carcinoma in Situ (BONBIS)

Active, not recruitingNCT00907868

Institut du Cancer de Montpellier - Val d'AurelleBreast Cancer

Start: 2008-11-01End: 2029-10-01Updated: 2026-02-05

Partial Breast Irradiation in a Low-risk Population Screened With MRI

WithdrawnNCT01255553

University of ChicagoBreast Cancer

Start: 2009-06-30End: 2012-05-31Updated: 2014-03-04

Breast Cancer With Low Risk Of Local Recurrence: Partial and Accelerated Radiation With Three-Dimensional Conformal Radiotherapy (3DCRT) Vs. Standard Radiotherapy After Conserving Surgery (Phase III Study

CompletedNCT01803958

Regione Emilia-RomagnaBreast Cancer

Start: 2007-04-30End: 2019-01-31Updated: 2019-03-27

Partial Breast Irradiation for Low-risk Ductal Carcinoma In Situ After Breast-conserving Surgery

Fudan UniversityBreast Cancer

Start: 2015-10-31Target: 828Updated: 2015-11-30

Pre- Versus Postoperative Accelerated Partial Breast Irradiation

TerminatedNCT02913729

The Netherlands Cancer InstituteBreast Cancer, Cancer of the Breast, Neoplasms, Breast

Start: 2016-11-10End: 2022-02-28Updated: 2022-09-29

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

RecruitingNCT02945579

M.D. Anderson Cancer CenterEstrogen Receptor Negative, HER2/Neu Negative, HER2 Positive Breast Carcinoma +9

Start: 2017-01-20End: 2028-01-31Target: 120Updated: 2026-03-09

Impact of 5-fraction Stereotactic Partial Breast Irradiation and Whole Breast Irradiation on Cosmetic Outcome and Patient-reported Outcomes in Early-stage Breast Cancer

Yonsei UniversityBreast Cancer

Start: 2018-04-11End: 2023-04-11Target: 200Updated: 2018-06-26

Super-Hypofractionated Partial Breast Irradiation

RecruitingNCT06615466

Cancer Institute and Hospital, Chinese Academy of Medical SciencesBreast Cancer, Radiotherapy Side Effect

Start: 2022-04-22End: 2027-09-30Target: 50Updated: 2024-09-26

Related Papers

Financial Toxicity of Shorter Versus Longer Partial Breast Irradiation: A Randomized Clinical Trial.

2026-06-15

Late Toxicities and Quality of Life After a Radiation Boost for Breast Ductal Carcinoma In Situ: Boost or No Boost in DCIS Randomized Trial.

2025-07-31

Abstract PS6-04: Eliminating breast surgery for invasive, hormone-positive breast cancers with an exceptional response to endocrine therapy and ablative radiotherapy: a single-arm, phase 2 trial

Clinical Cancer Research2025-06-13

Selective Elimination of Breast Surgery for Invasive Breast Cancer

JAMA Oncology2025-03-2821 citations

Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy

JAMA Network Open2023-09-1410 citations

Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial—a study protocol

BMC Cancer2023-05-0918 citations

Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy: a multicentre, single-arm, phase 2 trial.

2022-10-25115 citations

Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial

Journal of Clinical Oncology2022-08-0574 citations

Quality assurance program and early toxicities in the phase III BONBIS randomized trial evaluating the role of a localized radiation boost in ductal carcinoma in situ.

2021-09-248 citations

Accuracy of Magnetic Resonance Imaging–Guided Biopsy to Verify Breast Cancer Pathologic Complete Response After Neoadjuvant Chemotherapy

JAMA Network Open2021-01-1535 citations

First Experience in Korea of Stereotactic Partial Breast Irradiation for Low-Risk Early-Stage Breast Cancer

Frontiers in Oncology2020-04-2912 citations

Accuracy of core biopsy in predicting pathologic complete response in the breast in patients with complete/near complete clinical and radiological response (Complete Responders in the Breast - CRBr) - Trial design and conduct

International Journal of Surgery Protocols2019-01-016 citations

Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial.

2017-08-02406 citations

Avoiding Breast Cancer Surgery After Neoadjuvant Chemotherapy

Oncology Times2017-06-13