Paracetamol Biofarm

DRUG3 trials

Sponsors

Paradigm Biopharmaceuticals (USA) Inc., KRKA tovarna zdravil d.d. Novo mesto

Conditions

Knee osteoarthritisKnee osteoarthritis pain

Phase 2

A 2-stage, Adaptive, Randomised, Double-blind, Placebo-controlled, Multicentre Study to Evaluate Dose and Treatment Effect of Pentosan Polysulfate Sodium Compared with Placebo in Participants with Knee Osteoarthritis Pain

WithdrawnCTIS2022-500228-31-00

Paradigm Biopharmaceuticals (USA) Inc.Knee osteoarthritis pain

Target: 40Updated: 2022-06-27

A 2-stage, Adaptive, Randomised, Double-blind, Placebo-controlled, Multicentre Study to Evaluate Dose and Treatment Effect of Pentosan Polysulfate Sodium Compared with Placebo in Participants with Knee Osteoarthritis Pain

CompletedCTIS2022-500228-31-01

Paradigm Biopharmaceuticals (USA) Inc.Knee osteoarthritis pain

Start: 2023-03-31End: 2023-11-09Target: 80Updated: 2023-03-03

Phase 4

The effects of 2-week long treatment with naproxen sodium (Nalgesin® Forte) on synovial fluid cytokine and naproxen concentration and clinical outcomes in patients with knee osteoarthritis – ZOOM-IN: A randomized, double-blind, placebo-controlled, parallel, multicenter clinical trial

CompletedCTIS2023-505875-56-00

KRKA tovarna zdravil d.d. Novo mestoKnee osteoarthritis

Start: 2025-05-21End: 2025-09-17Target: 38Updated: 2025-10-21