FindTrial
Sign In

Panobinostat (LBH589)

DRUG8 trials

Sponsors

Novartis Pharmaceuticals, H. Lee Moffitt Cancer Center and Research Institute, University of Wisconsin, Madison, Tulane University Health Sciences Center, Technical University of Munich

Conditions

Acute Myeloid LeukemiaAdvanced Solid TumorsBreast CancerChronic Myelomonocytic LeukemiaCutaneous T-Cell LymphomaGraft-Versus-Host DiseaseHead and Neck CancerLeukemia-Lymphoma, Adult T-Cell

Early Phase 1

ERB-B4 After Treatment With HDAC Inhibitor in ER+ Tamoxifen Refractory Breast Cancer
WithdrawnNCT00993642
Tulane University Health Sciences CenterBreast Cancer
Start: 2009-09-30End: 2010-12-31Updated: 2017-03-13

Phase 1

Phase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract Cancers
CompletedNCT00738751
H. Lee Moffitt Cancer Center and Research InstituteHead and Neck Cancer, Lung Cancer
Start: 2008-11-30End: 2015-02-28Updated: 2015-02-04
A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML).
CompletedNCT00946647
Novartis PharmaceuticalsAcute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
Start: 2009-12-02End: 2019-04-29Updated: 2020-08-04
Study to Evaluate Panobinostat (DACi) Pharmacokinetics and Safety in Solid Tumors and Varying Renal Function
CompletedNCT00997399
Novartis PharmaceuticalsAdvanced Solid Tumors
Start: 2010-03-31End: 2014-06-30Updated: 2020-12-19
Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD)
CompletedNCT01111526
H. Lee Moffitt Cancer Center and Research InstituteGraft-Versus-Host Disease
Start: 2010-04-30End: 2016-06-30Updated: 2018-05-15

Phase 2

Study of Oral LBH589 in Patients With Cutaneous T-cell Lymphoma and Adult T-cell Leukemia/Lymphoma
TerminatedNCT00699296
Novartis PharmaceuticalsCutaneous T-Cell Lymphoma, Leukemia-Lymphoma, Adult T-Cell
Start: 2008-05-31Updated: 2012-11-27
Study of Panobinostat in Patients With Neuroendocrine Tumors
TerminatedNCT00985946
University of Wisconsin, MadisonNeuroendocrine Tumors
Start: 2010-05-31End: 2015-04-30Updated: 2019-12-09
Histone Deacetylases - Gastric Cancer (HDAC-GaCa-2008)
TerminatedNCT01528501
Technical University of MunichMetastatic Gastric Cancer
Start: 2009-06-30Target: 28Updated: 2013-05-01