Oxidative Phosphorylation Inhibitor IACS-010759

DRUG2 trials

Sponsors

M.D. Anderson Cancer Center

Conditions

Advanced Malignant Solid NeoplasmAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8Anatomic Stage IIIB Breast Cancer AJCC v8Anatomic Stage IIIC Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Estrogen Receptor NegativeHER2/Neu Negative

Phase 1

Oxidative Phosphorylation Inhibitor IACS-010759 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

TerminatedNCT02882321

M.D. Anderson Cancer CenterRecurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia

Start: 2016-09-29End: 2022-04-15Updated: 2023-06-15

IACS-010759 in Advanced Cancers

CompletedNCT03291938

M.D. Anderson Cancer CenterAdvanced Malignant Solid Neoplasm, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8 +22

Start: 2017-11-13End: 2020-11-23Updated: 2020-11-24

Related Papers

Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials.

2023-01-19280 citations

Mitochondrial Oxphos As Survival Mechanism of Minimal Residual AML Cells after Induction Chemotherapy : Survival Benefit By Complex I Inhibition with Iacs-010759

Blood2019-11-1317 citations

Phase I trial of IACS-010759 (IACS), a potent, selective inhibitor of complex I of the mitochondrial electron transport chain, in patients (pts) with advanced solid tumors.

Journal of Clinical Oncology2019-05-2066 citations

Ibrutinib-Resistant Mantle Cell Lymphoma Undergoes Metabolic Reprogramming Towards Oxphos

Blood2018-11-29

Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors

Cancer Research2018-07-015 citations

Inhibition of Oxphos with Iacs-010759 Depletes AML Leukemia Initiating Cells (LIC) in Vitro and Improves Survival in Pre-Clinical AML Models

Blood2017-12-072 citations