Oxfendazole

DRUG9 trials

Sponsors

Johns Hopkins Bloomberg School of Public Health, National Institute of Allergy and Infectious Diseases (NIAID), Oxfendazole Development Group, Asociacion Benefica Prisma, Swiss Tropical & Public Health Institute

Conditions

FascioliasisFilariasisHelminthiasisHelminthic InfectionLoiasisNeurocysticercosisTenia Solium InfectionTrichuriasis

Phase 1

Single Ascending Dose Safety Study of Oxfendazole

WithdrawnNCT01584362

Johns Hopkins Bloomberg School of Public HealthTenia Solium Infection

Start: 2016-08-31End: 2016-08-31Updated: 2016-08-30

Phase I Trial Evaluating the Safety and Pharmacokinetics of Oxfendazole

CompletedNCT02234570

National Institute of Allergy and Infectious Diseases (NIAID)Neurocysticercosis

Start: 2014-11-17End: 2015-11-24Updated: 2020-11-02

Multiple Ascending Dose Study of Oxfendazole in Healthy Adult Volunteers

CompletedNCT03035760

National Institute of Allergy and Infectious Diseases (NIAID)Helminthic Infection

Start: 2017-05-12End: 2019-04-23Updated: 2019-12-17

PK, Safety and Tolerability of Single and Multiple Doses of Oxfendazole Tablets

CompletedNCT04920292

Swiss Tropical & Public Health InstituteFilariasis

Start: 2022-04-21End: 2022-11-14Updated: 2022-12-20

Phase 2

Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults

WithdrawnNCT02636803

Johns Hopkins Bloomberg School of Public HealthHelminthiasis

Start: 2019-11-30End: 2021-02-28Updated: 2019-08-15

Efficacy of Oxfendazole in the Treatment of Trichuris Trichiura Infection in Adults

Not yet recruitingNCT03435718

Oxfendazole Development GroupTrichuris Infection

Start: 2024-07-31End: 2026-10-31Target: 250Updated: 2023-11-08

A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults

RecruitingNCT04713787

Asociacion Benefica PrismaTrichuriasis

Start: 2024-09-07End: 2027-05-30Target: 249Updated: 2026-07-28

One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole in Chronic Fascioliasis

Not yet recruitingNCT06367361

Universidad Peruana Cayetano HerediaFascioliasis

Start: 2026-08-15End: 2029-04-15Target: 336Updated: 2026-06-03

A randomized, dose escalation, phase II, proof of concept trial evaluating the activity of oxfendazole for the treatment of loiasis

Active, not recruitingPACTR202411787280874

Centre de Recherches Medicales de Lambarene CERMELLoiasis

Start: 2024-12-01Target: 60Updated: 2026-09-14

Related Papers

Pharmacokinetics, safety, and tolerability of an oxfendazole tablet formulation: a phase 1, randomized, placebo-controlled trial in healthy African volunteers.

2026-02-18

Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open-Label Phase 1 Multiple Ascending Dose and Food Effect Study.

2020-10-2016 citations

Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study.

2019-03-2731 citations