Oxaliplatin 5mg/ml concentrate for solution for infusion
Sponsors
Leap Therapeutics Inc., Glaxosmithkline Research & Development Limited, Amsterdam UMC, Pfizer Inc., AbbVie Deutschland GmbH & Co. KG
Conditions
Colorectal CancerColorectal cancer (BRAF V600E-mutant mCRC)Gastric AdenocarcinomaGastric cancerGastroEsophageal CancerParticipants with Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon CancerRectum cancerRelapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)
Phase 1
Phase 2
Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
CompletedCTIS2022-501465-40-00
Start: 2023-12-22End: 2025-07-02Target: 25Updated: 2025-06-12
A Phase 2, Multicenter, Open-Label Study of DKN-01 in Combination with Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy in Adult Patients with Inoperable, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (DisTinGuish)
CompletedCTIS2023-504940-32-00
Start: 2023-10-13End: 2025-02-17Target: 15Updated: 2024-09-26
Liposomal iRInotecan, Carboplatin or oXaliplatin in the first line treatment of esophagogastric cancer: a randomized phase 2 study (LyRICX)
Active, not recruitingCTIS2023-509287-26-00
Start: 2019-07-01Target: 322Updated: 2025-11-04
Phase 3
A Phase 3, Open-Label, Randomized Study of Perioperative Dostarlimab Monotherapy versus Standard of Care in Participants with Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Active, not recruitingCTIS2023-503265-27-00
Start: 2023-11-23Target: 477Updated: 2025-10-20
C4221015 - AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST LINE ENCORAFENIB PLUS CETUXIMAB WITH OR WITHOUT CHEMOTHERAPY
VERSUS STANDARD OF CARE THERAPY WITH A SAFETY LEAD-IN OF ENCORAFENIB AND CETUXIMAB PLUS CHEMOTHERAPY IN PARTICIPANTS WITH METASTATIC BRAF V600E MUTANT COLORECTAL CANCER
Active, not recruitingCTIS2023-509405-77-00
Start: 2021-02-16Target: 300Updated: 2026-01-26
C4221015 - AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST LINE ENCORAFENIB PLUS CETUXIMAB WITH OR WITHOUT CHEMOTHERAPY
VERSUS STANDARD OF CARE THERAPY WITH A SAFETY LEAD-IN OF ENCORAFENIB AND CETUXIMAB PLUS CHEMOTHERAPY IN PARTICIPANTS WITH METASTATIC BRAF V600E MUTANT COLORECTAL CANCER
Active, not recruitingCTIS2023-509405-77-00
Start: 2021-02-16Target: 300Updated: 2026-01-26
A Phase 3, Multicenter, Randomized, Open-Label Study of Epcoritamab Plus Lenalidomide Compared to Rituximab Plus Gemcitabine and Oxaliplatin in Participants with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
RecruitingCTIS2024-510965-41-00
Start: 2024-09-03Target: 116Updated: 2025-12-15