Otelixizumab

DRUG7 trials

Sponsors

GlaxoSmithKline

Conditions

Arthritis, RheumatoidDiabetes Mellitus, Type 1Graves Ophthalmopathy

Phase 1

Subcutaneous Administration of Otelixizumab to T1DM Patients

CompletedNCT00946257

GlaxoSmithKlineDiabetes Mellitus, Type 1

Start: 2009-07-08End: 2013-06-25Updated: 2017-06-01

Safety, Pharmacodynamics and Pharmacokinetics of GSK2136525 Repeat Dose in Rheumatoid Arthritis

TerminatedNCT01077531

GlaxoSmithKlineArthritis, Rheumatoid

Start: 2010-04-28End: 2013-03-19Updated: 2017-06-08

Investigation of Otelixizumab in New-Onset, Autoimmune Type 1 Diabetes Mellitus Patients

CompletedNCT02000817

GlaxoSmithKlineDiabetes Mellitus, Type 1

Start: 2014-03-12End: 2018-09-27Updated: 2019-06-24

Phase 2

TRX4 Monoclonal Antibody in Type 1 Diabetes (T1 DM)

TerminatedNCT00451321

GlaxoSmithKlineDiabetes Mellitus, Type 1

Start: 2006-07-31End: 2011-12-01Updated: 2017-11-13

A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease

TerminatedNCT01114503

GlaxoSmithKlineGraves Ophthalmopathy

Start: 2010-07-07End: 2012-08-29Updated: 2020-10-30

Investigating Re-Dosing With Otelixizumab in Adults With Newly-Diagnosed Type 1 Diabetes Mellitus

TerminatedNCT01222078

GlaxoSmithKlineDiabetes Mellitus, Type 1

Start: 2010-11-22End: 2011-05-19Updated: 2020-10-30

Phase 3

Trial of Otelixizumab for Adolescents and Adults With Newly Diagnosed Type 1 Diabetes Mellitus (Autoimmune): DEFEND-2

CompletedNCT01123083

GlaxoSmithKlineDiabetes Mellitus, Type 1

Start: 2010-05-17End: 2012-03-09Updated: 2017-09-15

Related Papers

Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation.

2024-12-204 citations

A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes.

2020-11-0437 citations

How many unpublished studies? ClinicalTrials.gov (n = 2614 studies): diabetes | Closed Studies | Interventional Studies | Phase 3, 4 | Search Date: Oct 27, 2014

Figshare2014-01-01