Optimal medical treatment

DRUG12 trials

Sponsors

Danish Study Group, Karolinska Institutet, Seung-Jung Park, Navy General Hospital, Beijing, National Institute of Cardiology, Warsaw, Poland

Conditions

Acute Mitral RegurgitationCardiogenic ShockChronic Myeloid Leukemia (CML)Coronary Artery DiseaseCryptogenic StrokeDiabetic Kidney DiseaseDilated CardiomyopathyHeart Failure

Phase 3

Evaluation of a Cardiovascular Active Prevention in Chronic Myeloid Leukemia on the Cardiovascular Morbi-mortality

TerminatedNCT03746054

University Hospital, AngersChronic Myeloid Leukemia (CML)

Start: 2019-12-20End: 2024-04-16Updated: 2025-03-17

Phase 4

Preventive PCI or Medical Therapy Alone for Vulnerable Atherosclerotic Coronary Plaque

CompletedNCT02316886

Seung-Jung ParkCoronary Artery Disease, Plaque, Atherosclerotic

Start: 2015-10-05End: 2023-10-19Updated: 2023-11-18

Unknown Phase

Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality

CompletedNCT00541268

Danish Study GroupDilated Cardiomyopathy, Heart Failure, Reduced LVEF

Start: 2008-02-29End: 2016-07-31Updated: 2022-04-08

Danish ICD Study in Patients With Dilated Cardiomyopathy

CompletedNCT00542945

Danish Study GroupDilated Cardiomyopathy, Heart Failure, Reduced LVEF

Start: 2008-03-31End: 2016-06-30Updated: 2019-07-18

Prevention of Microvascular Complications in Overweight Diabetics With Surgery or Best Medicine

WithdrawnNCT02011178

Karolinska InstitutetDiabetic Kidney Disease

Start: 2014-03-31End: 2017-12-31Updated: 2017-03-13

Effect of Daily Remote Ischemic Conditioning on the Life Quality of Refractory Angina Pectoris Patients

Navy General Hospital, BeijingRefractory Angina Pectoris

Start: 2015-01-31End: 2017-01-31Target: 30Updated: 2015-07-16

Dietary Intervention to Stop COronary Atherosclerosis in Computed Tomography

National Institute of Cardiology, Warsaw, PolandCoronary Artery Disease

Start: 2015-10-31End: 2018-10-31Target: 180Updated: 2015-11-16

Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions

CompletedNCT03421834

University Medical Centre LjubljanaIschemic Cardiomyopathy, Ventricular Tachycardia

Start: 2018-02-06End: 2024-01-04Updated: 2024-01-09

The Current Status and Clinical Outcomes of Patients With Cardiogenic Shock II

Samsung Medical CenterCardiogenic Shock

Start: 2019-05-30End: 2024-12-31Target: 1000Updated: 2019-11-01

Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure

RecruitingNCT05907694

Josep Rodes-CabauCryptogenic Stroke, Medical Treatment, Older Patients +2

Start: 2024-06-18End: 2037-10-01Target: 714Updated: 2026-03-27

Early Transcatheter Mitral Valve Repair After Myocardial Infarction

RecruitingNCT06282042

Fundación para la Investigación Biosanitaria del Principado de AsturiasAcute Mitral Regurgitation

Start: 2024-12-24End: 2028-06-16Target: 250Updated: 2025-10-17

RestoratIon of Myocardial Function by PeRcutaneous cOronary interVEntion in Patients With Ischemic CardioMyoPathy

RecruitingNCT06930092

Seoul National University HospitalIschemic Cardiomyopathy

Start: 2025-08-03End: 2029-04-30Target: 158Updated: 2026-04-24

Related Papers

Long-Term Effect of ICDs in Nonischemic Heart Failure With Reduced Ejection Fraction: Extended Follow-Up Analysis of DANISH.

2025-10-221 citations

Implantable Cardioverter-Defibrillator and Frailty in Non-ischemic Heart Failure With Reduced Ejection Fraction: Extended Follow-Up of the DANISH Trial.

2025-09-23

Atrial fibrillation and implantable cardioverter-defibrillator in non-ischaemic heart failure with reduced ejection fraction: insights from the DANISH trial

EP Europace2025-08-28

Anthropometric Measures and Long-Term Mortality in Non-Ischaemic Heart Failure with Reduced Ejection Fraction: Questioning the Obesity Paradox

European Journal of Heart Failure2024-08-1811 citations

New York Heart Association Functional Class and Implantable Cardioverter-Defibrillator in Non-Ischaemic Heart Failure with Reduced Ejection Fraction: Extended Follow-Up of the DANISH Trial

European Journal of Heart Failure2024-05-112 citations

Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial.

2024-04-08145 citations

Estimated Glomerular Filtration Rate and Implantable Cardioverter‐Defibrillator in Nonischemic Systolic Heart Failure: Extended Follow‐Up of DANISH

Journal of the American Heart Association2024-01-31

Preventive PCI or medical therapy alone for vulnerable atherosclerotic coronary plaque: Rationale and design of the randomized, controlled PREVENT trial.

2023-06-0219 citations

Efficacy of Implantable Cardioverter Defibrillator in Nonischemic Systolic Heart Failure According to Sex: Extended Follow-Up Study of the DANISH Trial

Circulation Heart Failure2022-09-016 citations

Anatomic and Hemodynamic Plaque Characteristics for Subsequent Coronary Events

Frontiers in Cardiovascular Medicine2022-05-2314 citations

NT-proBNP and ICD in Nonischemic Systolic Heart Failure: Extended Follow-Up of the DANISH Trial.

2022-03-019 citations

Long-Term Follow-Up of DANISH (The Danish Study to Assess the Efficacy of ICDs in Patients With Nonischemic Systolic Heart Failure on Mortality)

Circulation2021-12-0965 citations

Identification of anatomic risk factors for acute coronary events by optical coherence tomography in patients with myocardial infarction and residual nonflow limiting lesions: rationale and design of the PECTUS-obs study

BMJ Open2021-07-0115 citations

High-Risk Coronary Plaque Regression After Intensive Lifestyle Intervention in Nonobstructive Coronary Disease: A Randomized Study.

2020-12-1659 citations

Quality of life and the associated risk of all-cause mortality in nonischemic heart failure.

2020-02-047 citations

P2680Changes in body fat distribution after intensive dietary intervention in patients with stable coronary artery disease

European Heart Journal2019-10-011 citations

Duration of Heart Failure and Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure

Circulation Heart Failure2019-09-012 citations

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions.

2019-07-2412 citations

Risk Models for Prediction of Implantable Cardioverter-Defibrillator Benefit: Insights From the DANISH Trial.

2019-07-1029 citations

Impaired myocardial perfusion is associated with increasing end-systolic- and end-diastolic volumes in patients with non-ischemic systolic heart failure: a cross-sectional study using Rubidium-82 PET/CT.

2019-03-223 citations

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