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Optimal medical therapy (OMT)

DRUG6 trials

Sponsors

Duke University, The University of Texas Health Science Center, Houston, Helios Health Institute GmbH, Charite University, Berlin, Germany, University of Aarhus

Conditions

Coronary Artery DiseaseHeart FailureMitral Valve InsufficiencyMyocardial InfarctionPercutaneous Transluminal AngioplastyRenal Artery Stenosis AtheroscleroticRenovascular HypertensionRenovascular Hypertension With Renal Failure

Phase 3

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
TerminatedNCT00608140
Duke UniversityHeart Failure, Mitral Valve Insufficiency
Start: 2008-03-31End: 2010-03-31Updated: 2018-04-04

Unknown Phase

Combined Pressure and Flow Measurements to Guide Treatment of Coronary Stenoses
CompletedNCT02328820
The University of Texas Health Science Center, HoustonCoronary Artery Disease
Start: 2014-10-31End: 2021-04-30Updated: 2021-04-06
Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death
WithdrawnNCT04540289
Helios Health Institute GmbHMyocardial Infarction, Sudden Cardiac Death
Start: 2021-02-01End: 2023-01-31Updated: 2023-03-08
Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death
WithdrawnNCT04540354
Helios Health Institute GmbHHeart Failure, Myocardial Infarction, Sudden Cardiac Death
Start: 2021-02-01End: 2023-01-31Updated: 2023-03-08
Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation
RecruitingNCT05665608
Charite University, Berlin, GermanyMyocardial Infarction, Sudden Cardiac Death
Start: 2023-11-16End: 2027-11-30Target: 3595Updated: 2026-04-01
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
RecruitingNCT05834803
University of AarhusHeart Failure, Percutaneous Transluminal Angioplasty, Renal Artery Stenosis Atherosclerotic +2
Start: 2023-06-26End: 2027-06-01Target: 80Updated: 2026-04-23

Related Papers

Economic evaluation protocol for the PRevention Of sudden cardiac death aFter myocardial Infarction by Defibrillator implantation: the PROFID EHRA trial.
2026-01-08
PRevention of sudden cardiac death aFter myocardial infarction by defibrillator implantation: Design and rationale of the PROFID EHRA randomized clinical trial
American Heart Journal2025-08-062 citations
Coronary Microvascular Dysfunction Alters the Pulsatile Behavior of the Resting Coronary Blood Flow
Microcirculation2025-08-011 citations
The impact of high microvascular resistance on coronary wave energetics depends on coronary microvascular functionality
European Heart Journal Open2025-04-305 citations
Influence of Pathophysiologic Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes
Circulation2024-05-1456 citations
Clinical and Vessel Characteristics Associated With Hard Outcomes After PCI and Their Combined Prognostic Implications.
2023-08-292 citations
Impact of core laboratory assessment on treatment decisions and clinical outcomes using combined fractional flow reserve and coronary flow reserve measurements - DEFINE-FLOW core laboratory sub-study.
2023-01-119 citations
Procedural Outcomes After Percutaneous Coronary Interventions in Focal and Diffuse Coronary Artery Disease
Journal of the American Heart Association2022-11-2937 citations
Prognostic value of microvascular resistance and its association to fractional flow reserve: a DEFINE-FLOW substudy
Open Heart2022-04-0116 citations
Non-randomized comparison between revascularization and deferral for intermediate coronary stenosis with abnormal fractional flow reserve and preserved coronary flow reserve.
2021-04-281 citations
Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions.
2020-07-2220 citations
Coronary Flow Capacity to Identify Stenosis Associated With Coronary Flow Improvement After Revascularization: A Combined Analysis From DEFINE FLOW and IDEAL.
2020-07-1412 citations
Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study.
2017-01-133 citations