OPC-41061
Sponsors
Otsuka Pharmaceutical Co., Ltd.
Conditions
Autosomal Dominant Polycystic Kidney DiseaseCarcinomatous EdemaChronic Renal FailureCirrhosisHealthy Adult Male
Phase 1
Phase 2
A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Study 156-04-001]
CompletedNCT00841568
Start: 2006-04-30End: 2010-11-30Updated: 2018-09-11
A Multicenter, Open-label, Dose-finding Trial of OPC-41061 to Investigate Efficacy, Pharmacokinetics, Pharmacodynamics, and Safety in Patients With Carcinomatous Edema (Phase 2)
CompletedNCT01684202
Start: 2012-07-31End: 2014-06-30Updated: 2021-03-18
A Phase 2, Multi-center, Open-label, Dose-finding Trial to Investigate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of OPC-41061 in Patients With Chronic Renal Failure Undergoing Hemodialysis or Hemodiafiltration
CompletedNCT01876381
Start: 2013-06-30End: 2014-02-28Updated: 2018-08-24
Open-label Dose-finding Trial of OPC-41061 in Patients With Chronic Renal Failure Undergoing Peritoneal Dialysis
CompletedNCT01895322
Start: 2013-07-31End: 2014-08-31Updated: 2016-01-01
A Trial to Investigate the Efficacy and Safety of Orally Administered Tolvaptan (OPC-41061) in Patients With Chronic Renal Failure Undergoing Hemodialysis or Hemodiafiltration
CompletedNCT02331680
Start: 2014-12-31End: 2016-05-31Updated: 2019-10-22
Phase 3
A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) [Extension of Study 156-05-002]
CompletedNCT01022424
Start: 2009-11-30End: 2014-07-31Updated: 2018-09-11
A Trial of OPC-41061 in Patients With Hepatic Edema - Investigation of the Safety of Treatment at 7.5 mg Beyond 7 Days and of the Effect of Dose Escalation to 15 mg
CompletedNCT01048788
Start: 2009-12-31End: 2011-08-31Updated: 2016-04-11
A Trial to Investigate the Efficacy of OPC-41061 Administered at a Dose of 7.5 mg in Patients With Hepatic Edema
CompletedNCT01050530
Start: 2009-12-31End: 2012-02-29Updated: 2014-03-04
A Study to Investigate Pharmacodynamics and Pharmacokinetics of OPC-41061 in Patients With Hepatic Edema
CompletedNCT01114828
Start: 2010-02-28End: 2011-12-31Updated: 2014-03-04