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OPC-34712

DRUG14 trials

Sponsors

Otsuka Pharmaceutical Development & Commercialization, Inc., Otsuka Pharmaceutical Co., Ltd.

Conditions

Acute SchizophreniaDepressionDepressive DisorderDepressive Disorder, MajorHealthy Adult MaleMajor Depressive DisorderMental DisordersMood Disorders

Phase 1

Positron Emission Tomagraphy (PET) Study Following a Single Oral Dose of OPC-34712
CompletedNCT00805454
Otsuka Pharmaceutical Development & Commercialization, Inc.Schizophrenia
Start: 2008-12-31End: 2009-07-31Updated: 2010-05-07
Trial Evaluating OPC-34712 in Subjects With Normal Renal Function and Renally Impaired Subjects
CompletedNCT01289080
Otsuka Pharmaceutical Development & Commercialization, Inc.Psychiatric Disorders, Schizophrenia
Start: 2011-01-31End: 2012-01-31Updated: 2015-10-29
A Study Evaluating the of OPC-34712 in Subjects With Normal Hepatic Function and Hepatically Impaired Subjects
CompletedNCT01299454
Otsuka Pharmaceutical Development & Commercialization, Inc.Schizophrenia
Start: 2010-12-31End: 2011-07-31Updated: 2015-10-20
Evaluation Study of the Bioavailability of Brexpiprazole Orally Disintegrating Tablets in Healthy Male Subjects
CompletedNCT02875080
Otsuka Pharmaceutical Co., Ltd.Healthy Adult Male
Start: 2016-09-27End: 2016-11-27Updated: 2021-02-23

Phase 2

Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
CompletedNCT00797966
Otsuka Pharmaceutical Development & Commercialization, Inc.Major Depressive Disorder
Start: 2009-05-31End: 2010-07-31Updated: 2016-02-29
Study to Evaluate the Efficacy, Safety, and Tolerability of Oral OPC-34712 and Aripiprazole for Treatment of Acute Schizophrenia
CompletedNCT00905307
Otsuka Pharmaceutical Development & Commercialization, Inc.Schizophrenia
Start: 2009-07-31End: 2010-11-30Updated: 2015-10-20
Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder
CompletedNCT01052077
Otsuka Pharmaceutical Development & Commercialization, Inc.Major Depressive Disorder
Start: 2010-03-31End: 2011-11-30Updated: 2015-11-02
Study of Safety & Tolerability of OPC-34712 as Adjunctive Therapy in Treatment of Adult Patients With Major Depressive Disorder
CompletedNCT01447576
Otsuka Pharmaceutical Development & Commercialization, Inc.Major Depressive Disorder
Start: 2009-09-30End: 2012-12-31Updated: 2015-11-06
A Dose-finding Trial of OPC-34712 in Patients With Schizophrenia
CompletedNCT01451164
Otsuka Pharmaceutical Co., Ltd.Schizophrenia
Start: 2011-10-31Updated: 2019-10-03
Multicenter, Open-label, Safety and Tolerability Study
CompletedNCT01649557
Otsuka Pharmaceutical Development & Commercialization, Inc.Schizophrenia
Start: 2009-08-31End: 2011-09-30Updated: 2015-10-29

Phase 3

Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)
CompletedNCT01360866
Otsuka Pharmaceutical Development & Commercialization, Inc.Depression, Depressive Disorder, Depressive Disorder, Major +2
Start: 2011-10-31End: 2017-05-18Updated: 2018-09-17
Efficacy Study of OPC-34712 in Adults With Acute Schizophrenia
CompletedNCT01393613
Otsuka Pharmaceutical Development & Commercialization, Inc.Acute Schizophrenia
Start: 2011-07-31End: 2014-02-28Updated: 2015-11-26
Safety and Tolerability Study of Oral OPC-34712 as Maintenance Treatment in Adults With Schizophrenia
CompletedNCT01397786
Otsuka Pharmaceutical Development & Commercialization, Inc.Schizophrenia
Start: 2011-09-30End: 2016-01-31Updated: 2017-05-10
A Long-term Trial of OPC-34712 in Patients With Schizophrenia
CompletedNCT01456897
Otsuka Pharmaceutical Co., Ltd.Schizophrenia
Start: 2011-10-31Updated: 2019-12-30

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14 Long-term Efficacy of Brexpiprazole in Patients with Schizophrenia with Clinically Relevant Levels of Negative Symptoms
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Changes in metabolic parameters and body weight in brexpiprazole-treated patients with acute schizophrenia: pooled analyses of phase 3 clinical studies.
2018-07-2720 citations
T50. SYMPTOMATIC AND FUNCTIONAL RESPONSE TO BREXPIP RAZOLE TREATMENT IN PATIENTS WITH ACUTE SCHIZOPHRENIA BY AGE
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A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Maintenance Treatment in Adults with Schizophrenia
The International Journal of Neuropsychopharmacology2018-01-2648 citations
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Schizophrenia Bulletin2017-03-011 citations

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