Ontamalimab

DRUG7 trials

Sponsors

Shire, Takeda

Conditions

Crohn's DiseaseSteatohepatitisUlcerative Colitis

Phase 1

A Study to Evaluate How Ontamalimab Works and Assess Its Safety and Tolerability in People With Nonalcoholic Steatohepatitis With Fibrosis Stages 1 to 4

TerminatedNCT07052682

TakedaSteatohepatitis

Start: 2023-01-18End: 2024-12-30Updated: 2025-08-19

Phase 3

Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis

TerminatedNCT03259334

ShireUlcerative Colitis

Start: 2018-02-09End: 2020-10-23Updated: 2021-06-14

Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis

TerminatedNCT03259308

ShireUlcerative Colitis

Start: 2017-12-05End: 2020-10-06Updated: 2021-04-26

An Efficacy and Safety Study of Ontamalimab as Maintenance Therapy in Participants With Moderate to Severe Ulcerative Colitis

CompletedNCT03290781

ShireUlcerative Colitis

Start: 2018-04-04End: 2021-07-01Updated: 2022-01-14

Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 305)

TerminatedNCT03559517

ShireCrohn's Disease

Start: 2018-08-29End: 2020-10-08Updated: 2021-04-29

Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 306)

TerminatedNCT03566823

ShireCrohn's Disease

Start: 2018-07-17End: 2020-08-18Updated: 2021-05-11

Efficacy and Safety Study of Ontamalimab as Maintenance Treatment in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 307)

TerminatedNCT03627091

ShireCrohn's Disease

Start: 2019-02-06End: 2021-09-13Updated: 2022-03-31

Related Papers

Efficacy and Safety of the Anti-mucosal Addressin Cell Adhesion Molecule-1 Antibody Ontamalimab in Patients with Moderate-to-Severe Ulcerative Colitis or Crohn’s Disease

Journal of Crohn s and Colitis2023-12-1316 citations

S906 Clinical Remission Using the Patient-Reported Ulcerative Colitis Electronic Diary (UC e-Diary) in Adults With Moderate-to-Severe Ulcerative Colitis

The American Journal of Gastroenterology2021-10-01

S905 Psychometric Properties of the Ulcerative Colitis Electronic Diary (UC e-Diary) in Adult Patients with Moderate-to-Severe Ulcerative Colitis

The American Journal of Gastroenterology2021-10-01

Antibodies to watch in 2020.

2020-01-01328 citations